TY - JOUR
T1 - Pattern of relapse in paediatric acute lymphoblastic leukaemia in a tertiary care unit
AU - Siddiqui, Emad Uddin
AU - Kazi, Sayyeda Ghazala
AU - Habib, Muhammad Irfan
AU - Ahmed Khan, Khalid Mehmood
AU - Zia, Nukhba
N1 - Publisher Copyright:
© 2016, Pakistan Medical Association. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Objective: To determine the frequency, site and time to relapse from diagnosis, and to see the relationship of relapse with important prognostic factors. Methods: The prospective descriptive observational study was conducted at the National Institute of Child Health, Karachi, June 2005 to May 2007, and comprised newly-diagnosed cases of acute lymphoblastic leukaemia. Bone marrow aspiration was done on reappearance of blast cells in peripheral smear and cerebrospinal fluid. Detailed report was done each time when intra-thecal chemotherapy was given or there were signs and symptoms suggestive of central nervous system relapse. SPSS 12 was used for data analysis. Results: Of the 60 patients enrolled, 4(6.6%) expired and 1(1.7%) was lost to follow-up. Of the 55(91.6%) who comprised the study sample, 35(58%) were males and 25(42%) females. Mean age of relapse was 6.8±3.27 years. Mean time to relapse from diagnosis was 1.3±0.54 years; 12(20%) patients suffered relapse, and of them 5(14%) were boys. Central nervous system relapse in 8(67%) patients was the most common site, with 3(25%) bone-marrow relapses. Out of 12 patient with relapses, 9(75%) had white blood cell count less than 50,000/cm. Conclusion: Relapse in acute lymphoblastic leukaemia was common, although treatment modalities are improving day by day.
AB - Objective: To determine the frequency, site and time to relapse from diagnosis, and to see the relationship of relapse with important prognostic factors. Methods: The prospective descriptive observational study was conducted at the National Institute of Child Health, Karachi, June 2005 to May 2007, and comprised newly-diagnosed cases of acute lymphoblastic leukaemia. Bone marrow aspiration was done on reappearance of blast cells in peripheral smear and cerebrospinal fluid. Detailed report was done each time when intra-thecal chemotherapy was given or there were signs and symptoms suggestive of central nervous system relapse. SPSS 12 was used for data analysis. Results: Of the 60 patients enrolled, 4(6.6%) expired and 1(1.7%) was lost to follow-up. Of the 55(91.6%) who comprised the study sample, 35(58%) were males and 25(42%) females. Mean age of relapse was 6.8±3.27 years. Mean time to relapse from diagnosis was 1.3±0.54 years; 12(20%) patients suffered relapse, and of them 5(14%) were boys. Central nervous system relapse in 8(67%) patients was the most common site, with 3(25%) bone-marrow relapses. Out of 12 patient with relapses, 9(75%) had white blood cell count less than 50,000/cm. Conclusion: Relapse in acute lymphoblastic leukaemia was common, although treatment modalities are improving day by day.
KW - Acute lymphoblastic leukaemia
KW - Blast cells
KW - Bone marrow
KW - Relapse
UR - http://www.scopus.com/inward/record.url?scp=84978043852&partnerID=8YFLogxK
M3 - Article
C2 - 27524528
AN - SCOPUS:84978043852
SN - 0030-9982
VL - 66
SP - 961
EP - 967
JO - Journal of the Pakistan Medical Association
JF - Journal of the Pakistan Medical Association
IS - 8
ER -