TY - JOUR
T1 - Pediatric disease burden and vaccination recommendations
T2 - understanding local differences
AU - Gentile, Angela
AU - Bhutta, Zulfiqar
AU - Bravo, Lulu
AU - Samy, Aly Gamal
AU - Garcia, R. Dennis J.
AU - Hoosen, Anwar
AU - Islam, Tazul
AU - Karimi, Abdollah
AU - Salem, Mona
AU - Simasathien, Sriluck
AU - Sohail, Amir
AU - Watanaveeradej, Veerachai
AU - Wiedenmayer, Karin
AU - Schmitt, Heinz J.
N1 - Funding Information:
Conflict of interest statement: Angela Gentile, Zulfiqar Bhutta, Anwar Hoosen, Tazul Islam, Abdollah Karimi, and Amir Sohail have no competing interests to disclose. Lulu Bravo has received an honorarium from Novartis Vaccines for presenting. Aly Gamal Samy has received honoraria from Novartis Vaccines for presenting and serving on an advisory board. R. Dennis J. Garcia and Mona Salem have received honoraria from Novartis Vaccines for attendance at an advisory board. Karin Wiedenmayer has received an honorarium from Novartis Vaccines for presenting and serving on an advisory board and has conducted research funded by Novartis Vaccines. Sriluck Simasathien and Veerachai Watanaveeradej received sponsorship to attend the 13 th International Congress on Infectious Diseases, Kuala Lumpur, 2008 from Novartis Vaccines and honoraria for attending the Quinvaxem advisory board meeting at that congress. Heinz-J. Schmitt is an employee of Novartis Vaccines and Diagnostics GmbH & Co. KG, Marburg, Germany and holds Novartis stocks.
PY - 2010/8
Y1 - 2010/8
N2 - Background: Diphtheria (D), tetanus (T), pertussis (P), hepatitis B (HepB), invasive Haemophilus influenzae type b (Hib) disease, and measles cause substantial global morbidity and mortality. Methods: This unique review highlights geographic differences in disease burden across certain countries in the African, Americas, Mediterranean, South-East Asian, and Western Pacific World Health Organization (WHO) regions, and relates this to vaccination coverage and local vaccine recommendations using the authors' countries as illustrations. Results: Substantial differences were observed in the incidence of these diseases and in vaccination coverage between the countries studied. Disease incidence often reflected inadequate surveillance, but also variable or poor vaccination coverage. Vaccination coverage against HepB was particularly low in the African and South-East Asian WHO regions; vaccination coverage against invasive Hib disease was low in these regions and in the Eastern Mediterranean and Western Pacific WHO regions. Vaccination schedules within some countries in these regions do not include, or have only recently included, vaccinations against HepB and Hib disease. The use of DTwP-HepB-Hib (diphtheria, tetanus, whole-cell pertussis, HepB, Hib) combination vaccines has now been adopted by some countries to help increase vaccination coverage. Conclusions: Vaccination coverage and vaccination schedules vary markedly between the countries studied, often according to the resources available. DTwP-HepB-Hib combination vaccines represent a cost-effective option, with the potential to substantially reduce the burden associated with these diseases by increasing coverage and compliance.
AB - Background: Diphtheria (D), tetanus (T), pertussis (P), hepatitis B (HepB), invasive Haemophilus influenzae type b (Hib) disease, and measles cause substantial global morbidity and mortality. Methods: This unique review highlights geographic differences in disease burden across certain countries in the African, Americas, Mediterranean, South-East Asian, and Western Pacific World Health Organization (WHO) regions, and relates this to vaccination coverage and local vaccine recommendations using the authors' countries as illustrations. Results: Substantial differences were observed in the incidence of these diseases and in vaccination coverage between the countries studied. Disease incidence often reflected inadequate surveillance, but also variable or poor vaccination coverage. Vaccination coverage against HepB was particularly low in the African and South-East Asian WHO regions; vaccination coverage against invasive Hib disease was low in these regions and in the Eastern Mediterranean and Western Pacific WHO regions. Vaccination schedules within some countries in these regions do not include, or have only recently included, vaccinations against HepB and Hib disease. The use of DTwP-HepB-Hib (diphtheria, tetanus, whole-cell pertussis, HepB, Hib) combination vaccines has now been adopted by some countries to help increase vaccination coverage. Conclusions: Vaccination coverage and vaccination schedules vary markedly between the countries studied, often according to the resources available. DTwP-HepB-Hib combination vaccines represent a cost-effective option, with the potential to substantially reduce the burden associated with these diseases by increasing coverage and compliance.
KW - Diphtheria
KW - Haemophilus influenzae type b
KW - Hepatitis B
KW - Measles
KW - Pertussis
KW - Tetanus
UR - http://www.scopus.com/inward/record.url?scp=77954957120&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2009.11.006
DO - 10.1016/j.ijid.2009.11.006
M3 - Review article
C2 - 20181506
AN - SCOPUS:77954957120
SN - 1201-9712
VL - 14
SP - e649-e658
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
IS - 8
ER -