Pediatric Hodgkin's lymphoma: Changing concepts and moving points in radiation therapy

Yasser M. Khafaga, Asim F. Belgaumi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


The classic treatment of Hodgkin's lymphoma (HL) in children resulted in significant late toxicity in long-term survivors. Late treatment effects included skeletal, cardio- pulmonary, gonadal toxicities, and second malignant tumor (SMN). This has driven pediatric HL groups to adopt treatment strategies using less intense chemotherapy, less alkylating agents, reduced radiation dose and volume, and omission of radiation therapy in selected group of patients. In limited disease, the aim is to maintain a high cure rate with minimal side effects. Patients with advanced-stage HL have a lower outcome, and need treatment intensification. Dose-dense, risk and response-adapted treatment strategies are evolving aiming at improving outcome and reducing toxicity.

Original languageEnglish
Pages (from-to)56-62
Number of pages7
JournalTransfusion and Apheresis Science
Issue number1
Publication statusPublished - Aug 2013
Externally publishedYes


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