TY - JOUR
T1 - Percutaneous coronary intervention in patients with cardiac allograft vasculopathy
T2 - a Nationwide Inpatient Sample (NIS) database analysis
AU - Ullah, Waqas
AU - Thalambedu, Nishant
AU - Zahid, Salman
AU - Zia Khan, Muhammad
AU - Mir, Tanveer
AU - Roomi, Sohaib
AU - Fischman, David L.
AU - Virani, Salim S.
AU - Alam, Mahboob
N1 - Funding Information:
This paper was supported by. Department of Veterans Affairs, World Heart Federation, Tahir and Jooma Family Honorarium: American College of Cardiology (Associate Editor for Innovations, acc.org).
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Cardiac allograft vasculopathy (CAV) is a major cause of heart transplant failure and mortality. The role of percutaneous coronary intervention (PCI) in these patients remains unknown. Methods: The National Inpatient Sample (NIS) (2015–2017) was queried to identify all cases of CAV. The merits of PCI were determined using a propensity-matched multivariate logistic regression model. Adjusted odds ratios (aOR) for in-hospital complications were calculated. Results: A total of 2,380 patients (PCI 185, no-PCI 21,95) with CAV were included in the analysis. There was no significant difference in the odds of major bleeding (OR 1.87, 95% CI 0.94–3.7, P = 0.11), post-procedure bleeding (P = 0.37), cardiogenic shock (OR 0.87, 95% CI 0.45–1.69, P = 0.80), acute kidney injury (uOR 0.92, 95% CI 0.68–1.24, P = 0.64), cardiopulmonary arrest (OR 0.84, 95% CI 0.34–2.11, P = 0.88), and in-hospital mortality (OR 1.59, 95% CI 0.91–2.79, P = 0.14) between patients undergoing PCI compared to those treated conservatively. A propensity-matched analysis closely followed the results of unadjusted crude analysis. Conclusion: PCI in CAV may be associated with increased in-hospital complications and higher resource utilization.
AB - Cardiac allograft vasculopathy (CAV) is a major cause of heart transplant failure and mortality. The role of percutaneous coronary intervention (PCI) in these patients remains unknown. Methods: The National Inpatient Sample (NIS) (2015–2017) was queried to identify all cases of CAV. The merits of PCI were determined using a propensity-matched multivariate logistic regression model. Adjusted odds ratios (aOR) for in-hospital complications were calculated. Results: A total of 2,380 patients (PCI 185, no-PCI 21,95) with CAV were included in the analysis. There was no significant difference in the odds of major bleeding (OR 1.87, 95% CI 0.94–3.7, P = 0.11), post-procedure bleeding (P = 0.37), cardiogenic shock (OR 0.87, 95% CI 0.45–1.69, P = 0.80), acute kidney injury (uOR 0.92, 95% CI 0.68–1.24, P = 0.64), cardiopulmonary arrest (OR 0.84, 95% CI 0.34–2.11, P = 0.88), and in-hospital mortality (OR 1.59, 95% CI 0.91–2.79, P = 0.14) between patients undergoing PCI compared to those treated conservatively. A propensity-matched analysis closely followed the results of unadjusted crude analysis. Conclusion: PCI in CAV may be associated with increased in-hospital complications and higher resource utilization.
KW - CAV
KW - PCI
KW - Transplant
KW - cardiac allograft vasculopathy
KW - percutaneous coronary intervention
UR - http://www.scopus.com/inward/record.url?scp=85100555389&partnerID=8YFLogxK
U2 - 10.1080/14779072.2021.1882851
DO - 10.1080/14779072.2021.1882851
M3 - Article
C2 - 33507114
AN - SCOPUS:85100555389
SN - 1477-9072
VL - 19
SP - 269
EP - 276
JO - Expert Review of Cardiovascular Therapy
JF - Expert Review of Cardiovascular Therapy
IS - 3
ER -