Abstract
Objectives: To compare ion exchange and boronate affinity chromatography for HbA1c estimation in patients with type I and II diabetes having hemoglobin D. Design and methods: Systems based on ion exchange and boronate affinity chromatography were evaluated and compared for their performance for HbA1c estimation in patients with homozygous and heterozygous D disease. Results: Boronate affinity chromatography shows least interference by HbD in heterozygous as well as homozygous diabetic patients for HbA1c estimation. Conclusions: The use of boronate affinity chromatography was found to be helpful in evaluating glycemic control in diabetic subjects with HbD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1204-1210 |
| Number of pages | 7 |
| Journal | Clinical Biochemistry |
| Volume | 41 |
| Issue number | 14-15 |
| DOIs | |
| Publication status | Published - Oct 2008 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Chromatography
- Diabetes
- HbA
- HbD
- Hemoglobin variant
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