Perfusion Index as an Indicator for Mortality in Children with Plasmodium falciparum Severe Malaria

Wes Boland; Caitlin Bond; Ruth Namazzi; Paul Bangirana; Robert Opoka; Dibyadyuti Datta Datta; Chandy John

Perfusion Index as an Indicator for Mortality in Children with Plasmodium falciparum Severe Malaria

Wes Boland, Caitlin Bond, Ruth Namazzi, Paul Bangirana, Robert Opoka, Dibyadyuti Datta Datta, Chandy John

Medical College, East Africa

Research output: Contribution to journal › Article

Abstract

Background: Severe malaria (SM) remains a major global health problem causing ~275,000 pediatric deaths annually, worldwide. Continuous, non-invasive monitoring of peripheral perfusion can help detect abnormalities in systemic circulation, a common problem in critically ill patients, and can improve outcomes in children hospitalized with SM. Perfusion index (PI), an indicator of peripheral perfusion measured using a point-of-care pulse oximeter, is the ratio of pulsatile blood flow to static blood in peripheral tissue.

Objective :To investigate the role of PI as an indicator of adverse outcomes including mortality in children hospitalized with SM

Methods: We measured PI in a prospective cohort study of 600 children

Conclusion: The role of PI as an indicator of mortality in children with SM and the use of point-of-care tools for continuous monitoring of PI warrants further investigation in the management of SM to prevent or reduce the incidence of adverse outcomes.

Original language	Undefined/Unknown
Journal	Paediatrics and Child Health, East Africa
Publication status	Published - 1 Dec 2021

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

http://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/276

Cite this

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title = "Perfusion Index as an Indicator for Mortality in Children with Plasmodium falciparum Severe Malaria",

abstract = "Background: Severe malaria (SM) remains a major global health problem causing ~275,000 pediatric deaths annually, worldwide. Continuous, non-invasive monitoring of peripheral perfusion can help detect abnormalities in systemic circulation, a common problem in critically ill patients, and can improve outcomes in children hospitalized with SM. Perfusion index (PI), an indicator of peripheral perfusion measured using a point-of-care pulse oximeter, is the ratio of pulsatile blood flow to static blood in peripheral tissue. Objective :To investigate the role of PI as an indicator of adverse outcomes including mortality in children hospitalized with SM Methods: We measured PI in a prospective cohort study of 600 children Conclusion: The role of PI as an indicator of mortality in children with SM and the use of point-of-care tools for continuous monitoring of PI warrants further investigation in the management of SM to prevent or reduce the incidence of adverse outcomes.",

author = "Wes Boland and Caitlin Bond and Ruth Namazzi and Paul Bangirana and Robert Opoka and Datta, {Dibyadyuti Datta} and Chandy John",

year = "2021",

month = dec,

day = "1",

language = "Undefined/Unknown",

journal = "Paediatrics and Child Health, East Africa",

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TY - JOUR

T1 - Perfusion Index as an Indicator for Mortality in Children with Plasmodium falciparum Severe Malaria

AU - Boland, Wes

AU - Bond, Caitlin

AU - Namazzi, Ruth

AU - Bangirana, Paul

AU - Opoka, Robert

AU - Datta, Dibyadyuti Datta

AU - John, Chandy

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Background: Severe malaria (SM) remains a major global health problem causing ~275,000 pediatric deaths annually, worldwide. Continuous, non-invasive monitoring of peripheral perfusion can help detect abnormalities in systemic circulation, a common problem in critically ill patients, and can improve outcomes in children hospitalized with SM. Perfusion index (PI), an indicator of peripheral perfusion measured using a point-of-care pulse oximeter, is the ratio of pulsatile blood flow to static blood in peripheral tissue. Objective :To investigate the role of PI as an indicator of adverse outcomes including mortality in children hospitalized with SM Methods: We measured PI in a prospective cohort study of 600 children Conclusion: The role of PI as an indicator of mortality in children with SM and the use of point-of-care tools for continuous monitoring of PI warrants further investigation in the management of SM to prevent or reduce the incidence of adverse outcomes.

AB - Background: Severe malaria (SM) remains a major global health problem causing ~275,000 pediatric deaths annually, worldwide. Continuous, non-invasive monitoring of peripheral perfusion can help detect abnormalities in systemic circulation, a common problem in critically ill patients, and can improve outcomes in children hospitalized with SM. Perfusion index (PI), an indicator of peripheral perfusion measured using a point-of-care pulse oximeter, is the ratio of pulsatile blood flow to static blood in peripheral tissue. Objective :To investigate the role of PI as an indicator of adverse outcomes including mortality in children hospitalized with SM Methods: We measured PI in a prospective cohort study of 600 children Conclusion: The role of PI as an indicator of mortality in children with SM and the use of point-of-care tools for continuous monitoring of PI warrants further investigation in the management of SM to prevent or reduce the incidence of adverse outcomes.

M3 - Article

JO - Paediatrics and Child Health, East Africa

JF - Paediatrics and Child Health, East Africa

ER -