Perfusion Index as an Indicator for Mortality in Children with Plasmodium falciparum Severe Malaria

Wes Boland, Caitlin Bond, Ruth Namazzi, Paul Bangirana, Robert Opoka, Dibyadyuti Datta Datta, Chandy John

Research output: Contribution to journalArticle


Background: Severe malaria (SM) remains a major global health problem causing ~275,000 pediatric deaths annually, worldwide. Continuous, non-invasive monitoring of peripheral perfusion can help detect abnormalities in systemic circulation, a common problem in critically ill patients, and can improve outcomes in children hospitalized with SM. Perfusion index (PI), an indicator of peripheral perfusion measured using a point-of-care pulse oximeter, is the ratio of pulsatile blood flow to static blood in peripheral tissue.

Objective :To investigate the role of PI as an indicator of adverse outcomes including mortality in children hospitalized with SM

Methods: We measured PI in a prospective cohort study of 600 children

Conclusion: The role of PI as an indicator of mortality in children with SM and the use of point-of-care tools for continuous monitoring of PI warrants further investigation in the management of SM to prevent or reduce the incidence of adverse outcomes.

Original languageUndefined/Unknown
JournalPaediatrics and Child Health, East Africa
Publication statusPublished - 1 Dec 2021

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