Perfusion Index as an Indicator for Mortality in Children with Plasmodium falciparum Severe Malaria

Wes Boland; Caitlin Bond; Ruth Namazzi; Paul Bangirana; Robert Opoka; Dibyadyuti Datta Datta; Chandy John

Perfusion Index as an Indicator for Mortality in Children with Plasmodium falciparum Severe Malaria

Wes Boland
, Caitlin Bond
, Ruth Namazzi
, Paul Bangirana
, Robert Opoka
, Dibyadyuti Datta Datta
, Chandy John

Medical College, East Africa

Research output: Contribution to journal › Article

Abstract

Background: Severe malaria (SM) remains a major global health problem causing ~275,000 pediatric deaths annually, worldwide. Continuous, non-invasive monitoring of peripheral perfusion can help detect abnormalities in systemic circulation, a common problem in critically ill patients, and can improve outcomes in children hospitalized with SM. Perfusion index (PI), an indicator of peripheral perfusion measured using a point-of-care pulse oximeter, is the ratio of pulsatile blood flow to static blood in peripheral tissue.

Objective :To investigate the role of PI as an indicator of adverse outcomes including mortality in children hospitalized with SM

Methods: We measured PI in a prospective cohort study of 600 children

Conclusion: The role of PI as an indicator of mortality in children with SM and the use of point-of-care tools for continuous monitoring of PI warrants further investigation in the management of SM to prevent or reduce the incidence of adverse outcomes.

Original language	Undefined/Unknown
Journal	Paediatrics and Child Health, East Africa
Publication status	Published - 1 Dec 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

http://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/276

Cite this

@article{aa6f9e2d3ab34ee9aa723c20e584a3f5,

title = "Perfusion Index as an Indicator for Mortality in Children with Plasmodium falciparum Severe Malaria",

abstract = "Background: Severe malaria (SM) remains a major global health problem causing \textasciitilde{}275,000 pediatric deaths annually, worldwide. Continuous, non-invasive monitoring of peripheral perfusion can help detect abnormalities in systemic circulation, a common problem in critically ill patients, and can improve outcomes in children hospitalized with SM. Perfusion index (PI), an indicator of peripheral perfusion measured using a point-of-care pulse oximeter, is the ratio of pulsatile blood flow to static blood in peripheral tissue. Objective :To investigate the role of PI as an indicator of adverse outcomes including mortality in children hospitalized with SM Methods: We measured PI in a prospective cohort study of 600 children Conclusion: The role of PI as an indicator of mortality in children with SM and the use of point-of-care tools for continuous monitoring of PI warrants further investigation in the management of SM to prevent or reduce the incidence of adverse outcomes.",

author = "Wes Boland and Caitlin Bond and Ruth Namazzi and Paul Bangirana and Robert Opoka and Datta, \{Dibyadyuti Datta\} and Chandy John",

year = "2021",

month = dec,

day = "1",

language = "Undefined/Unknown",

journal = "Paediatrics and Child Health, East Africa",

}

TY - JOUR

T1 - Perfusion Index as an Indicator for Mortality in Children with Plasmodium falciparum Severe Malaria

AU - Boland, Wes

AU - Bond, Caitlin

AU - Namazzi, Ruth

AU - Bangirana, Paul

AU - Opoka, Robert

AU - Datta, Dibyadyuti Datta

AU - John, Chandy

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Background: Severe malaria (SM) remains a major global health problem causing ~275,000 pediatric deaths annually, worldwide. Continuous, non-invasive monitoring of peripheral perfusion can help detect abnormalities in systemic circulation, a common problem in critically ill patients, and can improve outcomes in children hospitalized with SM. Perfusion index (PI), an indicator of peripheral perfusion measured using a point-of-care pulse oximeter, is the ratio of pulsatile blood flow to static blood in peripheral tissue. Objective :To investigate the role of PI as an indicator of adverse outcomes including mortality in children hospitalized with SM Methods: We measured PI in a prospective cohort study of 600 children Conclusion: The role of PI as an indicator of mortality in children with SM and the use of point-of-care tools for continuous monitoring of PI warrants further investigation in the management of SM to prevent or reduce the incidence of adverse outcomes.

AB - Background: Severe malaria (SM) remains a major global health problem causing ~275,000 pediatric deaths annually, worldwide. Continuous, non-invasive monitoring of peripheral perfusion can help detect abnormalities in systemic circulation, a common problem in critically ill patients, and can improve outcomes in children hospitalized with SM. Perfusion index (PI), an indicator of peripheral perfusion measured using a point-of-care pulse oximeter, is the ratio of pulsatile blood flow to static blood in peripheral tissue. Objective :To investigate the role of PI as an indicator of adverse outcomes including mortality in children hospitalized with SM Methods: We measured PI in a prospective cohort study of 600 children Conclusion: The role of PI as an indicator of mortality in children with SM and the use of point-of-care tools for continuous monitoring of PI warrants further investigation in the management of SM to prevent or reduce the incidence of adverse outcomes.

M3 - Article

JO - Paediatrics and Child Health, East Africa

JF - Paediatrics and Child Health, East Africa

ER -