TY - JOUR
T1 - Periprosthetic osteolysis
T2 - Genetics, mechanisms and potential therapeutic interventions
AU - Noordin, Shahryar
AU - Masri, Bassam
PY - 2012/12
Y1 - 2012/12
N2 - Aseptic loosening and periprosthetic osteolysis occur as a result of the biological response to particulate wear debris and are one of the leading causes of arthroplasty failure. Periprosthetic osteolysis originates from chronic inflammatory responses triggered by implant-derived particulate debris, which cause recruitment of cells, including macrophages, fibroblasts, lymphocytes and osteoclasts. These cells secrete pro - inflammatory and osteoclastogenic cytokines, exacerbating the inflammatory response. In addition to their direct activation by phagocytosis, there are contributing autocrine and paracrine effects that create a complex milieu within the periprosthetic space, which ultimately governs the development of osteolysis. Chronic cell activation may upset the delicate balance between bone formation and bone resorption leading to periprosthetic osteolysis. This article summarizes the genetic mechanisms underlying periprosthetic loosening and identifies potential therapeutic agents.
AB - Aseptic loosening and periprosthetic osteolysis occur as a result of the biological response to particulate wear debris and are one of the leading causes of arthroplasty failure. Periprosthetic osteolysis originates from chronic inflammatory responses triggered by implant-derived particulate debris, which cause recruitment of cells, including macrophages, fibroblasts, lymphocytes and osteoclasts. These cells secrete pro - inflammatory and osteoclastogenic cytokines, exacerbating the inflammatory response. In addition to their direct activation by phagocytosis, there are contributing autocrine and paracrine effects that create a complex milieu within the periprosthetic space, which ultimately governs the development of osteolysis. Chronic cell activation may upset the delicate balance between bone formation and bone resorption leading to periprosthetic osteolysis. This article summarizes the genetic mechanisms underlying periprosthetic loosening and identifies potential therapeutic agents.
UR - http://www.scopus.com/inward/record.url?scp=84872839731&partnerID=8YFLogxK
U2 - 10.1503/cjs.003711
DO - 10.1503/cjs.003711
M3 - Review article
C2 - 22992398
AN - SCOPUS:84872839731
SN - 0008-428X
VL - 55
SP - 408
EP - 417
JO - Canadian Journal of Surgery
JF - Canadian Journal of Surgery
IS - 6
ER -