Pharmacological basis for the medicinal use of cardamom in asthma

Arif ullah Khan; Qaiser Jabeen Khan; Anwarul Hassan Gilani

doi:10.3329/bjp.v6i1.8133

Pharmacological basis for the medicinal use of cardamom in asthma

Arif ullah Khan, Qaiser Jabeen Khan, Anwarul Hassan Gilani

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Cardamom (Elettaria cardamomum) is widely used in folk medicine for the treatment of asthma. This study describes its airways relaxant potential, with elucidation of possible underlying mechanism. Crude extract of cardamom which tested positive for alkaloids, flavonoids, saponins, sterols and tannins, when tested against carbachol-mediated bronchoconstriction in rats under anesthesia, dose-dependently (10-100 mg/kg) suppressed the carbachol (1 μmol/kg)-evoked increase in the inspiratory pressure. In isolated rabbit trachea tissues, crude extract of cardamom caused relaxation of both carbachol (1 μM) and high K ⁺ (80 mM)-induced contractions, like that caused by verapamil, suggesting its Ca ⁺⁺ channel blockade action. These results indicate that cardamom exhibits bronchodilatory effect, mediated through Ca ⁺⁺ antagonist mechanism, which provides sound mechanistic background for its medicinal use in asthma.

Original language	English
Pages (from-to)	34-37
Number of pages	4
Journal	Bangladesh Journal of Pharmacology
Volume	6
Issue number	1
DOIs	https://doi.org/10.3329/bjp.v6i1.8133
Publication status	Published - 2011
Externally published	Yes

Keywords

Asthma
Bronchodilation
Ca channel blocker
Cardamom

Access to Document

10.3329/bjp.v6i1.8133

Cite this

@article{73c6f129e7824d8e877b114c58acc44f,

title = "Pharmacological basis for the medicinal use of cardamom in asthma",

abstract = "Cardamom (Elettaria cardamomum) is widely used in folk medicine for the treatment of asthma. This study describes its airways relaxant potential, with elucidation of possible underlying mechanism. Crude extract of cardamom which tested positive for alkaloids, flavonoids, saponins, sterols and tannins, when tested against carbachol-mediated bronchoconstriction in rats under anesthesia, dose-dependently (10-100 mg/kg) suppressed the carbachol (1 μmol/kg)-evoked increase in the inspiratory pressure. In isolated rabbit trachea tissues, crude extract of cardamom caused relaxation of both carbachol (1 μM) and high K + (80 mM)-induced contractions, like that caused by verapamil, suggesting its Ca ++ channel blockade action. These results indicate that cardamom exhibits bronchodilatory effect, mediated through Ca ++ antagonist mechanism, which provides sound mechanistic background for its medicinal use in asthma.",

keywords = "Asthma, Bronchodilation, Ca channel blocker, Cardamom",

author = "Khan, {Arif ullah} and Khan, {Qaiser Jabeen} and Gilani, {Anwarul Hassan}",

year = "2011",

doi = "10.3329/bjp.v6i1.8133",

language = "English",

volume = "6",

pages = "34--37",

journal = "Bangladesh Journal of Pharmacology",

issn = "1991-007X",

publisher = "Bangladesh Pharmacological Society",

number = "1",

}

TY - JOUR

T1 - Pharmacological basis for the medicinal use of cardamom in asthma

AU - Khan, Arif ullah

AU - Khan, Qaiser Jabeen

AU - Gilani, Anwarul Hassan

PY - 2011

Y1 - 2011

N2 - Cardamom (Elettaria cardamomum) is widely used in folk medicine for the treatment of asthma. This study describes its airways relaxant potential, with elucidation of possible underlying mechanism. Crude extract of cardamom which tested positive for alkaloids, flavonoids, saponins, sterols and tannins, when tested against carbachol-mediated bronchoconstriction in rats under anesthesia, dose-dependently (10-100 mg/kg) suppressed the carbachol (1 μmol/kg)-evoked increase in the inspiratory pressure. In isolated rabbit trachea tissues, crude extract of cardamom caused relaxation of both carbachol (1 μM) and high K + (80 mM)-induced contractions, like that caused by verapamil, suggesting its Ca ++ channel blockade action. These results indicate that cardamom exhibits bronchodilatory effect, mediated through Ca ++ antagonist mechanism, which provides sound mechanistic background for its medicinal use in asthma.

AB - Cardamom (Elettaria cardamomum) is widely used in folk medicine for the treatment of asthma. This study describes its airways relaxant potential, with elucidation of possible underlying mechanism. Crude extract of cardamom which tested positive for alkaloids, flavonoids, saponins, sterols and tannins, when tested against carbachol-mediated bronchoconstriction in rats under anesthesia, dose-dependently (10-100 mg/kg) suppressed the carbachol (1 μmol/kg)-evoked increase in the inspiratory pressure. In isolated rabbit trachea tissues, crude extract of cardamom caused relaxation of both carbachol (1 μM) and high K + (80 mM)-induced contractions, like that caused by verapamil, suggesting its Ca ++ channel blockade action. These results indicate that cardamom exhibits bronchodilatory effect, mediated through Ca ++ antagonist mechanism, which provides sound mechanistic background for its medicinal use in asthma.

KW - Asthma

KW - Bronchodilation

KW - Ca channel blocker

KW - Cardamom

UR - http://www.scopus.com/inward/record.url?scp=84863764340&partnerID=8YFLogxK

U2 - 10.3329/bjp.v6i1.8133

DO - 10.3329/bjp.v6i1.8133

M3 - Article

AN - SCOPUS:84863764340

SN - 1991-007X

VL - 6

SP - 34

EP - 37

JO - Bangladesh Journal of Pharmacology

JF - Bangladesh Journal of Pharmacology

IS - 1

ER -

Pharmacological basis for the medicinal use of cardamom in asthma

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this