Pharmacological basis for the medicinal use of rhus coriaria in hyperactive gut disorders

Khalid Hussain Janbaz, Arham Shabbir, Malik Hassan Mehmood, Anwarul Hassan Gilani

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

This study was aimed at providing the pharmacological basis for the medicinal use of Rhus coriaria in diarrhea. In mice, the crude of R.coriaria demonstrated antisecretory and antidiarrheal effects against castor oil-induced fluid accumulation and diarrhea at at 100 and 300 mg/kg, respectively, and was found safe up to tested dose of 5 g/kg. In isolated rabbit jejunum, R. coriaria exhibited concentration-dependent (0.01-3.0 mg/mL) relaxation of spontaneous and high K+ (80 mM)-induced contractions, similar to verapamil. The Ca++ antagonist activity was confirmed when pretreatment of R. coriaria shifted Ca++ concentration-response curves to the right with suppression of maximal response, similar to verapamil. R.coriaria also suppressed the high K+-evoked transient contractile peaks similar to the effect of cyclopiazonic acid and verapamil. This study indicates that R. coriaria possesses antisecretory, antidiarrheal and antispasmodic properties mediated possibly through Ca++antagonist pathway, thus providing evidence to its medicinal use in diarrhea and abdominal spasm.

Original languageEnglish
Pages (from-to)636-644
Number of pages9
JournalBangladesh Journal of Pharmacology
Volume9
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Antidiarrheal
  • Antisecretory
  • Antispasmodic
  • Ca++ antagonist
  • Rhus coriaria

Fingerprint

Dive into the research topics of 'Pharmacological basis for the medicinal use of rhus coriaria in hyperactive gut disorders'. Together they form a unique fingerprint.

Cite this