TY - JOUR
T1 - Pharmacotherapy for Coronary Artery Disease and Acute Coronary Syndrome in the Aging Population
AU - Moras, Errol
AU - Zaid, Syed
AU - Gandhi, Kruti
AU - Barman, Nitin
AU - Birnbaum, Yochai
AU - Virani, Salim S.
AU - Tamis-Holland, Jacqueline
AU - Jneid, Hani
AU - Krittanawong, Chayakrit
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024/7
Y1 - 2024/7
N2 - Purpose of Review: To provide a comprehensive summary of relevant studies and evidence concerning the utilization of different pharmacotherapeutic and revascularization strategies in managing coronary artery disease and acute coronary syndrome specifically in the older adult population. Recent findings: Approximately 30% to 40% of hospitalized patients with acute coronary syndrome are older adults, among whom the majority of cardiovascular-related deaths occur. When compared to younger patients, these individuals generally experience inferior clinical outcomes. Most clinical trials assessing the efficacy and safety of various therapeutics have primarily enrolled patients under the age of 75, in addition to excluding those with geriatric complexities. Summary: In this review, we emphasize the need for a personalized and comprehensive approach to pharmacotherapy for coronary heart disease and acute coronary syndrome in older adults, considering concomitant geriatric syndromes and age-related factors to optimize treatment outcomes while minimizing potential risks and complications. In the realm of clinical practice, cardiovascular and geriatric risks are closely intertwined, with both being significant factors in determining treatments aimed at reducing negative outcomes and attaining health conditions most valued by older adults.
AB - Purpose of Review: To provide a comprehensive summary of relevant studies and evidence concerning the utilization of different pharmacotherapeutic and revascularization strategies in managing coronary artery disease and acute coronary syndrome specifically in the older adult population. Recent findings: Approximately 30% to 40% of hospitalized patients with acute coronary syndrome are older adults, among whom the majority of cardiovascular-related deaths occur. When compared to younger patients, these individuals generally experience inferior clinical outcomes. Most clinical trials assessing the efficacy and safety of various therapeutics have primarily enrolled patients under the age of 75, in addition to excluding those with geriatric complexities. Summary: In this review, we emphasize the need for a personalized and comprehensive approach to pharmacotherapy for coronary heart disease and acute coronary syndrome in older adults, considering concomitant geriatric syndromes and age-related factors to optimize treatment outcomes while minimizing potential risks and complications. In the realm of clinical practice, cardiovascular and geriatric risks are closely intertwined, with both being significant factors in determining treatments aimed at reducing negative outcomes and attaining health conditions most valued by older adults.
KW - Acute coronary syndromes
KW - Coronary artery disease
KW - Older adults
KW - Pharmacotherapy
KW - Revascularization
UR - http://www.scopus.com/inward/record.url?scp=85192552867&partnerID=8YFLogxK
U2 - 10.1007/s11883-024-01203-9
DO - 10.1007/s11883-024-01203-9
M3 - Review article
AN - SCOPUS:85192552867
SN - 1523-3804
VL - 26
SP - 231
EP - 248
JO - Current Atherosclerosis Reports
JF - Current Atherosclerosis Reports
IS - 7
ER -