Photoactivated TiO₂ nanowhiskers and tetra sulphonatophenyl porphyrin normoglycemic effect on diabetes mellitus during photodynamic therapy

Diabetes mellitus (DM) is one of the major human diseases resulting in hyperglycemia. Photodynamic therapy (PDT) is well-known for ablation of neoplastic tissues and amelioration of autoimmune diseases. Therefore, we explored the possible normoglycemic effect of TSPP-TiO₂ PDT on the DM (type I and II). We used three groups of DM murine models i.e., type I, type II and normal group. These results demonstrate that photoactivated TSPP-TiO₂ had significantly (p < 0.01) lowered the blood glucose level in type II DM group, whereas the type I DM group remained non-significant. Moreover, evaluation of the blood sugar level at various time intervals (1, 2, 8 and 24 hours) post PDT revealed a 31 and 33% decline after one and two hours respectively. These results suggest the normoglycemic effect of photoactivated TSPP-TiO₂ nanocomposites on type II DM that might be used for disease amelioration especially in insulin and drug resistant diabetes patients.