Placental Malaria and Perinatal Transmission of Human Immunodeficiency Virus Type 1

Ingrid Inion, Fabian Mwanyumba, Philippe Gaillard, Varsha Chohan, Chris Verhofstede, Patricia Claeys, Kishorchandra Mandaliya, Eric Van Marck, Marleen Temmerman

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64 Citations (Scopus)


Prevalence of placental malaria in human immunodeficiency virus (HIV) type 1-infected and -uninfected women and the effect of placental malaria on genital shedding and perinatal transmission of HIV-1 were examined. Genital samples for HIV-1 DNA RNA were collected during labor. Infants were tested for HIV-1 at 1 day and 6 weeks postpartum. Placental malaria was diagnosed by histopathological examination: 372 placentas of HIV-1-infected women and 277 of HIV-1-uninfected women were processed. A higher prevalence of placental malaria was seen in HIV-1-infected women. No association was found between placental malaria and either maternal virus load, genital HIV-1 DNA, or HIV-1 RNA. Placental malaria did not correlate with in utero or peripartal transmission of HIV-1.

Original languageEnglish
Pages (from-to)1675-1678
Number of pages4
JournalJournal of Infectious Diseases
Issue number11
Publication statusPublished - 1 Dec 2003
Externally publishedYes


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