Placental Malaria and Perinatal Transmission of Human Immunodeficiency Virus Type 1

Ingrid Inion; Fabian Mwanyumba; Philippe Gaillard; Varsha Chohan; Chris Verhofstede; Patricia Claeys; Kishorchandra Mandaliya; Eric Van Marck; Marleen Temmerman

doi:10.1086/379737

Placental Malaria and Perinatal Transmission of Human Immunodeficiency Virus Type 1

Ingrid Inion, Fabian Mwanyumba, Philippe Gaillard, Varsha Chohan, Chris Verhofstede, Patricia Claeys, Kishorchandra Mandaliya, Eric Van Marck, Marleen Temmerman

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64 Citations (Scopus)

Abstract

Prevalence of placental malaria in human immunodeficiency virus (HIV) type 1-infected and -uninfected women and the effect of placental malaria on genital shedding and perinatal transmission of HIV-1 were examined. Genital samples for HIV-1 DNA RNA were collected during labor. Infants were tested for HIV-1 at 1 day and 6 weeks postpartum. Placental malaria was diagnosed by histopathological examination: 372 placentas of HIV-1-infected women and 277 of HIV-1-uninfected women were processed. A higher prevalence of placental malaria was seen in HIV-1-infected women. No association was found between placental malaria and either maternal virus load, genital HIV-1 DNA, or HIV-1 RNA. Placental malaria did not correlate with in utero or peripartal transmission of HIV-1.

Original language	English
Pages (from-to)	1675-1678
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	188
Issue number	11
DOIs	https://doi.org/10.1086/379737
Publication status	Published - 1 Dec 2003
Externally published	Yes

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title = "Placental Malaria and Perinatal Transmission of Human Immunodeficiency Virus Type 1",

abstract = "Prevalence of placental malaria in human immunodeficiency virus (HIV) type 1-infected and -uninfected women and the effect of placental malaria on genital shedding and perinatal transmission of HIV-1 were examined. Genital samples for HIV-1 DNA RNA were collected during labor. Infants were tested for HIV-1 at 1 day and 6 weeks postpartum. Placental malaria was diagnosed by histopathological examination: 372 placentas of HIV-1-infected women and 277 of HIV-1-uninfected women were processed. A higher prevalence of placental malaria was seen in HIV-1-infected women. No association was found between placental malaria and either maternal virus load, genital HIV-1 DNA, or HIV-1 RNA. Placental malaria did not correlate with in utero or peripartal transmission of HIV-1.",

author = "Ingrid Inion and Fabian Mwanyumba and Philippe Gaillard and Varsha Chohan and Chris Verhofstede and Patricia Claeys and Kishorchandra Mandaliya and {Van Marck}, Eric and Marleen Temmerman",

note = "Funding Information: Received 20 February 2003; accepted 6 June 2003; electronically published 10 November 2003. Presented in part: XIV International AIDS Conference, Barcelona, Spain, July 7–12 2002 (abstract ThOrC 1490). Financial support: Elisabeth Glaser Pediatric AIDS Foundation (grant 51042). Reprints or correspondence: Dr. Marleen Temmerman, International Centre for Reproductive Health, Ghent University, De Pintelaan 185 P3, B-9000 Ghent, Belgium (marleen.temmerman @rug.ac.be).",

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doi = "10.1086/379737",

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AU - Inion, Ingrid

AU - Mwanyumba, Fabian

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AU - Chohan, Varsha

AU - Verhofstede, Chris

AU - Claeys, Patricia

AU - Mandaliya, Kishorchandra

AU - Van Marck, Eric

AU - Temmerman, Marleen

N1 - Funding Information: Received 20 February 2003; accepted 6 June 2003; electronically published 10 November 2003. Presented in part: XIV International AIDS Conference, Barcelona, Spain, July 7–12 2002 (abstract ThOrC 1490). Financial support: Elisabeth Glaser Pediatric AIDS Foundation (grant 51042). Reprints or correspondence: Dr. Marleen Temmerman, International Centre for Reproductive Health, Ghent University, De Pintelaan 185 P3, B-9000 Ghent, Belgium (marleen.temmerman @rug.ac.be).

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N2 - Prevalence of placental malaria in human immunodeficiency virus (HIV) type 1-infected and -uninfected women and the effect of placental malaria on genital shedding and perinatal transmission of HIV-1 were examined. Genital samples for HIV-1 DNA RNA were collected during labor. Infants were tested for HIV-1 at 1 day and 6 weeks postpartum. Placental malaria was diagnosed by histopathological examination: 372 placentas of HIV-1-infected women and 277 of HIV-1-uninfected women were processed. A higher prevalence of placental malaria was seen in HIV-1-infected women. No association was found between placental malaria and either maternal virus load, genital HIV-1 DNA, or HIV-1 RNA. Placental malaria did not correlate with in utero or peripartal transmission of HIV-1.

AB - Prevalence of placental malaria in human immunodeficiency virus (HIV) type 1-infected and -uninfected women and the effect of placental malaria on genital shedding and perinatal transmission of HIV-1 were examined. Genital samples for HIV-1 DNA RNA were collected during labor. Infants were tested for HIV-1 at 1 day and 6 weeks postpartum. Placental malaria was diagnosed by histopathological examination: 372 placentas of HIV-1-infected women and 277 of HIV-1-uninfected women were processed. A higher prevalence of placental malaria was seen in HIV-1-infected women. No association was found between placental malaria and either maternal virus load, genital HIV-1 DNA, or HIV-1 RNA. Placental malaria did not correlate with in utero or peripartal transmission of HIV-1.

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Placental Malaria and Perinatal Transmission of Human Immunodeficiency Virus Type 1

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