Abstract
Background: Elevated angiopoietin-2 (Angpt-2) concentrations are associated with worse overall neurocognitive function in severe malaria survivors, but the specifc domains afected have not been elucidated.
Methods: Ugandan children with severe malaria underwent neurocognitive evaluation a week after hospital discharge and at 6, 12 and 24 months follow-up. The relationship between Angpt-2 concentrations and age-adjusted, cognitive sub-scale z-scores over time were evaluated using linear mixed efects models, adjusting for disease severity (coma, acute kidney injury, number of seizures in hospital) and sociodemographic factors (age, gender, height-for-age z-score, socio-economic status, enrichment in the home environment, parental education, and any preschool education of the child). The Mullen Scales of Early Learning was used in children
Results: Increased admission Angpt-2 concentration was associated with worse outcomes in all domains (fne and gross motor, visual reception, receptive and expressive language) in children Conclusion: Elevated Angpt-2 concentration in children with severe malaria is associated with worse outcomes in multiple neurocognitive domains. The relationship between Angpt-2 and worse cognition is evident in children
| Original language | Undefined/Unknown |
|---|---|
| Journal | Paediatrics and Child Health, East Africa |
| Publication status | Published - 1 Dec 2021 |
