@article{dbc9be74c5dc420bba8e7ea3e7171f52,
title = "Plasma proteomic signatures of enteric permeability among hospitalized and community children in Kenya and Pakistan",
abstract = "We aimed to establish if enteric permeability was associated with similar biological processes in children recovering from hospitalization and relatively healthy children in the community. Extreme gradient boosted models predicting the lactulose-rhamnose ratio (LRR), a biomarker of enteric permeability, using 7,500 plasma proteins and 34 fecal biomarkers of enteric infection among 89 hospitalized and 60 community children aged 2–23 months were built. The R2 values were calculated in test sets. The models performed better among community children (R2: 0.27 [min-max: 0.19, 0.53]) than hospitalized children (R2: 0.07 [min-max: 0.03, 0.11]). In the community, LRR was associated with biomarkers of humoral antimicrobial and cellular lipopolysaccharide responses and inversely associated with anti-inflammatory and innate immunological responses. Among hospitalized children, the selected biomarkers had few shared functions. This suggests enteric permeability among community children was associated with a host response to pathogens, but this association was not observed among hospitalized children.",
keywords = "Outcome, Patient characteristics, Pediatrics, Proteomics",
author = "Tickell, {Kirkby D.} and Denno, {Donna M.} and Ali Saleem and Zaubina Kazi and Singa, {Benson O.} and Catherine Achieng and Charles Mutinda and Richardson, {Barbra A.} and {\'A}sbj{\"o}rnsd{\'o}ttir, {Kristjana H.} and Hawes, {Stephen E.} and Berkley, {James A.} and Walson, {Judd L.}",
note = "Funding Information: This work was supported, in whole or in part, by the Bill & Melinda Gates Foundation [OPP1131320]. Under the grant conditions of the foundation, a Creative Commons Attribution 4.0 Generic License has already been assigned to the Author Accepted Manuscript version that might arise from this submission. The lactulose-rhamnose testing was funded by an Early Career Award from the Thrasher Research Foundation. The funders had no role in conduct of the study, interpretation, writing the manuscript, or decision to submit. No authors were paid to write this article by any company, organization, or agency. The sponsors had no role in the design of the study; the collection, analysis, or interpretation of the data; or the writing of this manuscript. The study was designed by KDT, DMD, AS, AZ, BS, BAR, KHA, SHE, JAB, and JLW. Study implementation was overseen by KDT, AS, AZ, BS, CA, and CM. Data were analyzed by KDT, and the manuscript was written by KDT. All authors contributed to editing the manuscript. The authors declare no competing interests. Funding Information: This work was supported, in whole or in part, by the Bill & Melinda Gates Foundation [ OPP1131320 ]. Under the grant conditions of the foundation, a Creative Commons Attribution 4.0 Generic License has already been assigned to the Author Accepted Manuscript version that might arise from this submission. The lactulose-rhamnose testing was funded by an Early Career Award from the Thrasher Research Foundation . The funders had no role in conduct of the study, interpretation, writing the manuscript, or decision to submit. No authors were paid to write this article by any company, organization, or agency. Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = aug,
day = "18",
doi = "10.1016/j.isci.2023.107294",
language = "English",
volume = "26",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier Inc.",
number = "8",
}