Plasmid mediated antibacterial resistance in Salmonella typhi

B. Farooqi, F. Shareeq, Q. K. Rizvi, M. Khurshid, N. Ahmed, N. Siddiqa, H. S. Qureshi, M. S. Mahmood, M. K. Ashfaq

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Salmonella typhi resistant to chloramphenicol, ampicillin and trimethoprim-sulphamethoxazole are simultaneously increasing in number worldwide. We isolated 290 Multiple drug resistant (MDR) S. typhi with high range of Minimum Inhibitory Concentrations (MICs). These isolates were sensitive to cefotaxime, ceftriaxone, zetreonam and ofloxacin with a narrow range of MICs. Tansconjugants E. coli showed same antibiogram and MICs as donor cells. All MDR S. typhi isolates and transconjugants contained a single plasmid pBN1 of 20kb. Purified plasmid of MDR S. typhi and transconjugants when treated with restriction endonuclease enzyme EcoR1 revealed no restriction site for EcoR1.

Original languageEnglish
Pages (from-to)107-109
Number of pages3
JournalJournal of the College of Physicians and Surgeons--Pakistan : JCPSP
Volume11
Issue number2
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Antibiotics
  • Drug resistance, multiple
  • Microbial sensitivity tests
  • Plasmids
  • Salmonella typhi

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