Plasmid mediated antibacterial resistance in Salmonella typhi

B. Farooqi; F. Shareeq; Q. K. Rizvi; M. Khurshid; N. Ahmed; A. Siddiqa; S. Qureshi Hina; M. S. Mahmood; M. K. Ashfaq

Plasmid mediated antibacterial resistance in Salmonella typhi

B. Farooqi, F. Shareeq, Q. K. Rizvi, M. Khurshid, N. Ahmed, A. Siddiqa, S. Qureshi Hina, M. S. Mahmood, M. K. Ashfaq

Research output: Contribution to journal › Article › peer-review

Abstract

Salmonella typhi resistant to chloramphenicol, ampicillin and trimethoprim-sulphamethoxazole are simultaneously increasing in number worldwide. We isolated 290 Multiple drug resistant (MDR) S. typhi with high range of Minimum Inhibitory Concentrations (MICs). These isolates were sensitive to cefotaxime, ceftriaxone, zetreonam and ofloxacin with a narrow range of MICs. Tansconjugants E. coli showed same antibiogram and MICs as donor cells. All MDR S. typhi isolates and transconjugants contained a single plasmid pBN1 of 20kb. Purified plasmid of MDR S. typhi and transconjugants when treated with restriction endonuclease enzyme EcoR1 revealed no restriction site for EcoR1.

Original language	English
Pages (from-to)	14-15
Number of pages	2
Journal	Medical Forum Monthly
Volume	11
Issue number	9
Publication status	Published - 2000
Externally published	Yes

Keywords

Antibiotics
Drug resistance, multiple
Microbial sensitivity tests
Plasmids
Salmonella typhi

Cite this

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title = "Plasmid mediated antibacterial resistance in Salmonella typhi",

abstract = "Salmonella typhi resistant to chloramphenicol, ampicillin and trimethoprim-sulphamethoxazole are simultaneously increasing in number worldwide. We isolated 290 Multiple drug resistant (MDR) S. typhi with high range of Minimum Inhibitory Concentrations (MICs). These isolates were sensitive to cefotaxime, ceftriaxone, zetreonam and ofloxacin with a narrow range of MICs. Tansconjugants E. coli showed same antibiogram and MICs as donor cells. All MDR S. typhi isolates and transconjugants contained a single plasmid pBN1 of 20kb. Purified plasmid of MDR S. typhi and transconjugants when treated with restriction endonuclease enzyme EcoR1 revealed no restriction site for EcoR1.",

keywords = "Antibiotics, Drug resistance, multiple, Microbial sensitivity tests, Plasmids, Salmonella typhi",

author = "B. Farooqi and F. Shareeq and Rizvi, {Q. K.} and M. Khurshid and N. Ahmed and A. Siddiqa and {Qureshi Hina}, S. and Mahmood, {M. S.} and Ashfaq, {M. K.}",

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language = "English",

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journal = "Medical Forum Monthly",

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TY - JOUR

T1 - Plasmid mediated antibacterial resistance in Salmonella typhi

AU - Farooqi, B.

AU - Shareeq, F.

AU - Rizvi, Q. K.

AU - Khurshid, M.

AU - Ahmed, N.

AU - Siddiqa, A.

AU - Qureshi Hina, S.

AU - Mahmood, M. S.

AU - Ashfaq, M. K.

PY - 2000

Y1 - 2000

N2 - Salmonella typhi resistant to chloramphenicol, ampicillin and trimethoprim-sulphamethoxazole are simultaneously increasing in number worldwide. We isolated 290 Multiple drug resistant (MDR) S. typhi with high range of Minimum Inhibitory Concentrations (MICs). These isolates were sensitive to cefotaxime, ceftriaxone, zetreonam and ofloxacin with a narrow range of MICs. Tansconjugants E. coli showed same antibiogram and MICs as donor cells. All MDR S. typhi isolates and transconjugants contained a single plasmid pBN1 of 20kb. Purified plasmid of MDR S. typhi and transconjugants when treated with restriction endonuclease enzyme EcoR1 revealed no restriction site for EcoR1.

AB - Salmonella typhi resistant to chloramphenicol, ampicillin and trimethoprim-sulphamethoxazole are simultaneously increasing in number worldwide. We isolated 290 Multiple drug resistant (MDR) S. typhi with high range of Minimum Inhibitory Concentrations (MICs). These isolates were sensitive to cefotaxime, ceftriaxone, zetreonam and ofloxacin with a narrow range of MICs. Tansconjugants E. coli showed same antibiogram and MICs as donor cells. All MDR S. typhi isolates and transconjugants contained a single plasmid pBN1 of 20kb. Purified plasmid of MDR S. typhi and transconjugants when treated with restriction endonuclease enzyme EcoR1 revealed no restriction site for EcoR1.

KW - Antibiotics

KW - Drug resistance, multiple

KW - Microbial sensitivity tests

KW - Plasmids

KW - Salmonella typhi

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M3 - Article

AN - SCOPUS:0034580272

SN - 1029-385X

VL - 11

SP - 14

EP - 15

JO - Medical Forum Monthly

JF - Medical Forum Monthly

IS - 9

ER -

Plasmid mediated antibacterial resistance in Salmonella typhi

Abstract

Keywords

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