Polymer networks synthesized from poly(Sorbitol adipate) and functionalized poly(ethylene glycol)

Haroon Rashid; Yury Golitsyn; Muhammad Humayun Bilal; Karsten Mäder; Detlef Reichert; Jörg Kressler

doi:10.3390/GELS7010022

Polymer networks synthesized from poly(Sorbitol adipate) and functionalized poly(ethylene glycol)

Haroon Rashid, Yury Golitsyn, Muhammad Humayun Bilal, Karsten Mäder, Detlef Reichert, Jörg Kressler

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Polymer networks were prepared by Steglich esterification using poly(sorbitol adipate) (PSA) and poly(sorbitol adipate)-graft-poly(ethylene glycol) mono methyl ether (PSA-g-mPEG₁₂ ) copolymer. Utilizing multi-hydroxyl functionalities of PSA, poly(ethylene glycol) (PEG) was first grafted onto a PSA backbone. Then the cross-linking of PSA or PSA-g-mPEG₁₂ was carried out with disuccinyl PEG of different molar masses (Suc-PEG_n-Suc). Polymers were characterized through nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC), and differential scanning calorimetry (DSC). The degree of swelling of networks was investigated through water (D₂O) uptake studies, while for detailed examination of their structural dynamics, networks were studied using¹³C magic angle spinning NMR (¹³C MAS NMR) spectroscopy,¹H double quantum NMR (¹H DQ NMR) spectroscopy, and¹H pulsed field gradient NMR (¹H PFG NMR) spectroscopy. These solid state NMR results revealed that the networks were composed of a two component structure, having different dipolar coupling constants. The diffusion of solvent molecules depended on the degree of swelling that was imparted to the network by the varying chain length of the PEG based cross-linking agent.

Original language	English (US)
Article number	22
Pages (from-to)	1-20
Number of pages	20
Journal	Gels
Volume	7
Issue number	1
DOIs	https://doi.org/10.3390/GELS7010022
Publication status	Published - 2021
Externally published	Yes

Keywords

Crosslinking
Enzymatic synthesis
Functional polyester
Hydrogel
Networks
PEG
Poly(sorbitol adipate)
Solid-state NMR
Steglich esterification
Sugar alcohol

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10.3390/GELS7010022

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title = "Polymer networks synthesized from poly(Sorbitol adipate) and functionalized poly(ethylene glycol)",

abstract = "Polymer networks were prepared by Steglich esterification using poly(sorbitol adipate) (PSA) and poly(sorbitol adipate)-graft-poly(ethylene glycol) mono methyl ether (PSA-g-mPEG12 ) copolymer. Utilizing multi-hydroxyl functionalities of PSA, poly(ethylene glycol) (PEG) was first grafted onto a PSA backbone. Then the cross-linking of PSA or PSA-g-mPEG12 was carried out with disuccinyl PEG of different molar masses (Suc-PEGn-Suc). Polymers were characterized through nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC), and differential scanning calorimetry (DSC). The degree of swelling of networks was investigated through water (D2O) uptake studies, while for detailed examination of their structural dynamics, networks were studied using13C magic angle spinning NMR (13C MAS NMR) spectroscopy,1H double quantum NMR (1H DQ NMR) spectroscopy, and1H pulsed field gradient NMR (1H PFG NMR) spectroscopy. These solid state NMR results revealed that the networks were composed of a two component structure, having different dipolar coupling constants. The diffusion of solvent molecules depended on the degree of swelling that was imparted to the network by the varying chain length of the PEG based cross-linking agent.",

keywords = "Crosslinking, Enzymatic synthesis, Functional polyester, Hydrogel, Networks, PEG, Poly(sorbitol adipate), Solid-state NMR, Steglich esterification, Sugar alcohol",

author = "Haroon Rashid and Yury Golitsyn and Bilal, \{Muhammad Humayun\} and Karsten M{\"a}der and Detlef Reichert and J{\"o}rg Kressler",

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doi = "10.3390/GELS7010022",

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volume = "7",

pages = "1--20",

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T1 - Polymer networks synthesized from poly(Sorbitol adipate) and functionalized poly(ethylene glycol)

AU - Rashid, Haroon

AU - Golitsyn, Yury

AU - Bilal, Muhammad Humayun

AU - Mäder, Karsten

AU - Reichert, Detlef

AU - Kressler, Jörg

PY - 2021

Y1 - 2021

N2 - Polymer networks were prepared by Steglich esterification using poly(sorbitol adipate) (PSA) and poly(sorbitol adipate)-graft-poly(ethylene glycol) mono methyl ether (PSA-g-mPEG12 ) copolymer. Utilizing multi-hydroxyl functionalities of PSA, poly(ethylene glycol) (PEG) was first grafted onto a PSA backbone. Then the cross-linking of PSA or PSA-g-mPEG12 was carried out with disuccinyl PEG of different molar masses (Suc-PEGn-Suc). Polymers were characterized through nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC), and differential scanning calorimetry (DSC). The degree of swelling of networks was investigated through water (D2O) uptake studies, while for detailed examination of their structural dynamics, networks were studied using13C magic angle spinning NMR (13C MAS NMR) spectroscopy,1H double quantum NMR (1H DQ NMR) spectroscopy, and1H pulsed field gradient NMR (1H PFG NMR) spectroscopy. These solid state NMR results revealed that the networks were composed of a two component structure, having different dipolar coupling constants. The diffusion of solvent molecules depended on the degree of swelling that was imparted to the network by the varying chain length of the PEG based cross-linking agent.

AB - Polymer networks were prepared by Steglich esterification using poly(sorbitol adipate) (PSA) and poly(sorbitol adipate)-graft-poly(ethylene glycol) mono methyl ether (PSA-g-mPEG12 ) copolymer. Utilizing multi-hydroxyl functionalities of PSA, poly(ethylene glycol) (PEG) was first grafted onto a PSA backbone. Then the cross-linking of PSA or PSA-g-mPEG12 was carried out with disuccinyl PEG of different molar masses (Suc-PEGn-Suc). Polymers were characterized through nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC), and differential scanning calorimetry (DSC). The degree of swelling of networks was investigated through water (D2O) uptake studies, while for detailed examination of their structural dynamics, networks were studied using13C magic angle spinning NMR (13C MAS NMR) spectroscopy,1H double quantum NMR (1H DQ NMR) spectroscopy, and1H pulsed field gradient NMR (1H PFG NMR) spectroscopy. These solid state NMR results revealed that the networks were composed of a two component structure, having different dipolar coupling constants. The diffusion of solvent molecules depended on the degree of swelling that was imparted to the network by the varying chain length of the PEG based cross-linking agent.

KW - Crosslinking

KW - Enzymatic synthesis

KW - Functional polyester

KW - Hydrogel

KW - Networks

KW - PEG

KW - Poly(sorbitol adipate)

KW - Solid-state NMR

KW - Steglich esterification

KW - Sugar alcohol

UR - https://www.scopus.com/pages/publications/85102773904

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DO - 10.3390/GELS7010022

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ER -

Polymer networks synthesized from poly(Sorbitol adipate) and functionalized poly(ethylene glycol)

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Keywords

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