Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan

Romena Qazi; Shazia Sultana; Shiyam Sundar; Haider Warraich; Tayyab un-Nisa; Abida Rais; Anita K.M. Zaidi

doi:10.1016/j.vaccine.2009.08.064

Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan

Romena Qazi, Shazia Sultana, Shiyam Sundar, Haider Warraich, Tayyab un-Nisa, Abida Rais, Anita K.M. Zaidi

Division of Woman and Child Health, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

The incidence of rotavirus-associated severe diarrhoea and distribution of rotavirus genotypes in children less than five years of age was determined in two low-income communities in Karachi, Pakistan. Over a two-year period, 717 children met eligibility criteria for severe diarrhoea and stools were obtained from 575 (80%) with 97 (17%) being rotavirus positive. Adjusted annual rates of severe rotavirus diarrhoea in children less than five years and less than one year were respectively 5.7 and 16.9 per 1000 in community A, and 8.1 and 25.4 per 1000 child years of observation in community B. An estimated 1 in 40 infants experience a severe episode of rotavirus gastroenteritis annually in Pakistan. The most common rotavirus strains were G9P[8] (15%), G1P[8] (13%) and G1[P4] (8.4%). This information will inform policy decisions about the introduction of rotavirus vaccines.

Original language	English
Pages (from-to)	F25-F30
Journal	Vaccine
Volume	27
Issue number	SUPPL. 5
DOIs	https://doi.org/10.1016/j.vaccine.2009.08.064
Publication status	Published - 20 Nov 2009

Keywords

Rotavirus
Surveillance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.vaccine.2009.08.064

Cite this

@article{95b8ce0893844183b48e9b7acefcb685,

title = "Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan",

abstract = "The incidence of rotavirus-associated severe diarrhoea and distribution of rotavirus genotypes in children less than five years of age was determined in two low-income communities in Karachi, Pakistan. Over a two-year period, 717 children met eligibility criteria for severe diarrhoea and stools were obtained from 575 (80%) with 97 (17%) being rotavirus positive. Adjusted annual rates of severe rotavirus diarrhoea in children less than five years and less than one year were respectively 5.7 and 16.9 per 1000 in community A, and 8.1 and 25.4 per 1000 child years of observation in community B. An estimated 1 in 40 infants experience a severe episode of rotavirus gastroenteritis annually in Pakistan. The most common rotavirus strains were G9P[8] (15%), G1P[8] (13%) and G1[P4] (8.4%). This information will inform policy decisions about the introduction of rotavirus vaccines.",

keywords = "Rotavirus, Surveillance",

author = "Romena Qazi and Shazia Sultana and Shiyam Sundar and Haider Warraich and Tayyab un-Nisa and Abida Rais and Zaidi, {Anita K.M.}",

note = "Funding Information: This work was performed under a collaborative agreement with the Program for Appropriate Technology in Health (PATH) and was funded in full or in part by the GAVI Alliance. ",

year = "2009",

month = nov,

day = "20",

doi = "10.1016/j.vaccine.2009.08.064",

language = "English",

volume = "27",

pages = "F25--F30",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

number = "SUPPL. 5",

}

TY - JOUR

T1 - Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan

AU - Qazi, Romena

AU - Sultana, Shazia

AU - Sundar, Shiyam

AU - Warraich, Haider

AU - un-Nisa, Tayyab

AU - Rais, Abida

AU - Zaidi, Anita K.M.

N1 - Funding Information: This work was performed under a collaborative agreement with the Program for Appropriate Technology in Health (PATH) and was funded in full or in part by the GAVI Alliance.

PY - 2009/11/20

Y1 - 2009/11/20

N2 - The incidence of rotavirus-associated severe diarrhoea and distribution of rotavirus genotypes in children less than five years of age was determined in two low-income communities in Karachi, Pakistan. Over a two-year period, 717 children met eligibility criteria for severe diarrhoea and stools were obtained from 575 (80%) with 97 (17%) being rotavirus positive. Adjusted annual rates of severe rotavirus diarrhoea in children less than five years and less than one year were respectively 5.7 and 16.9 per 1000 in community A, and 8.1 and 25.4 per 1000 child years of observation in community B. An estimated 1 in 40 infants experience a severe episode of rotavirus gastroenteritis annually in Pakistan. The most common rotavirus strains were G9P[8] (15%), G1P[8] (13%) and G1[P4] (8.4%). This information will inform policy decisions about the introduction of rotavirus vaccines.

AB - The incidence of rotavirus-associated severe diarrhoea and distribution of rotavirus genotypes in children less than five years of age was determined in two low-income communities in Karachi, Pakistan. Over a two-year period, 717 children met eligibility criteria for severe diarrhoea and stools were obtained from 575 (80%) with 97 (17%) being rotavirus positive. Adjusted annual rates of severe rotavirus diarrhoea in children less than five years and less than one year were respectively 5.7 and 16.9 per 1000 in community A, and 8.1 and 25.4 per 1000 child years of observation in community B. An estimated 1 in 40 infants experience a severe episode of rotavirus gastroenteritis annually in Pakistan. The most common rotavirus strains were G9P[8] (15%), G1P[8] (13%) and G1[P4] (8.4%). This information will inform policy decisions about the introduction of rotavirus vaccines.

KW - Rotavirus

KW - Surveillance

UR - http://www.scopus.com/inward/record.url?scp=71649110150&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2009.08.064

DO - 10.1016/j.vaccine.2009.08.064

M3 - Article

C2 - 19931714

AN - SCOPUS:71649110150

SN - 0264-410X

VL - 27

SP - F25-F30

JO - Vaccine

JF - Vaccine

IS - SUPPL. 5

ER -

Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this