Practical guidance on the use of laboratory testing in the management of bleeding in patients receiving direct oral anticoagulants

Hugo ten Cate, Yvonne McHenskens, Marcus D. Lancé

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)


Direct oral anticoagulants (DOACs) have demonstrated a favorable benefit–risk profile in several thromboembolic disorders and are increasingly used in routine clinical practice. A number of real-world studies on DOACs are ongoing, and data published so far have shown broadly similar outcomes to those demonstrated in the respective phase III trials. Despite their beneficial attributes, bleeding risk (as with any other anticoagulants) is often a concern for physicians when prescribing DOACs, particularly in elderly patients, those with significant comorbidities, and other high-risk patient populations. Although the absence of routine coagulation monitoring is an advantage of the DOACs, measuring their anticoagulant effect and/or plasma drug levels may be helpful in certain clinical scenarios to help patient management and improve outcomes. In this paper, practical guidance and recommendations are provided for clinical situations in which the test results may aid clinical decision-making, including patients with life-threatening bleeding events, patients without bleeding but with test results indicating a risk of bleeding, for those patients with a suspected thromboembolism while receiving a DOAC, or prior to patients undergoing elective or urgent surgical procedures. Finally, appropriate monitoring of the DOACs could be of substantial benefit to patients, and there is a high potential for development in this area in the future.

Original languageEnglish
Pages (from-to)457-467
Number of pages11
JournalVascular Health and Risk Management
Publication statusPublished - 13 Dec 2017
Externally publishedYes


  • Bleeding
  • Direct oral anticoagulants
  • Laboratory testing
  • Perioperative management
  • Practical guidance


Dive into the research topics of 'Practical guidance on the use of laboratory testing in the management of bleeding in patients receiving direct oral anticoagulants'. Together they form a unique fingerprint.

Cite this