TY - JOUR
T1 - PRECISE-DYAD
T2 - a prospective cohort study linking maternal and infant health trajectories in sub-Saharan Africa
AU - Volvert, Marie Laure
AU - Wilson, Milly
AU - Owino, Robin Okello
AU - Blencowe, Hannah
AU - Koech, Angela
AU - Jah, Hawanatu
AU - Idris, Yahaya
AU - Wanje, Onesmus
AU - Mwaniki, Isaac
AU - Mutunga, Joseph
AU - Touray, Fatima
AU - Mwadime, Emily
AU - Roca, Anna
AU - Omuse, Geoffrey
AU - Craik, Rachel
AU - Kongira, Fatoumata
AU - Mukhanya, Moses
AU - Bojang, Kalilu
AU - Njie, Baboucar
AU - Ochieng, Marvin
AU - D’Alessandro, Umberto
AU - Mwashigadi, Grace
AU - Mutua, Agnes Mutindi
AU - Rerimoi, Anne
AU - Temmerman, Marleen
AU - Akuze, Joseph
AU - Martinez-Alvarez, Melisa
AU - Magai, Dorcas N.
AU - Barratt, Ben
AU - Bah, Yorro
AU - Li, Jing
AU - Chandna, Jaya
AU - Gladstone, Melissa
AU - Abubakar, Amina
AU - Tribe, Rachel M.
AU - Khalil, Asma
AU - Makanga, Prestige Tatenda
AU - Salisbury, Tatiana Taylor
AU - Mistry, Hiten D.
AU - Moore, Sophie E.
AU - Nabwera, Helen
AU - Filippi, Veronique
AU - Magee, Laura A.
AU - Vidler, Marianne
AU - Makacha, Liberty
AU - Poston, Lucilla
AU - Sevene, Esperança
AU - Von Dadelszen, Peter
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
PY - 2026/7
Y1 - 2026/7
N2 - Purpose: The PREgnancy Care Integrating Translational Science, Everywhere (PRECISE)-DYAD Study is a prospective observational cohort designed to investigate health outcomes among mother-child pairs (dyads) over the first 3 years of life in two contexts from sub-Saharan Africa. The primary objective of the study was to explore the effects of selected placenta-related complications, such as pregnancy hypertension, fetal growth restriction and preterm birth, on (1) Child health and development, and (2) Women’s health and well-being, including outcomes after stillbirth. Participants: The PRECISE-DYAD Study enrolled women (and their children) originally recruited into the PRECISE pregnancy cohort study in The Gambia and Kenya between July 2021 and April 2024. Participants were seen at 6 weeks to 6 months, 12 months, 24 months and 36 months postpartum. Clinical and health data, including anthropometry and diet, were collected for both mothers and children. Mother assessment included a cardiology assessment and collection of data about symptoms of COVID-19 infection. In a subset of participants, mothers were asked about their mental health, their healthcare costs during and after pregnancy, and experiences of care during labour and childbirth/delivery. Additionally, a personal environmental exposure assessment was performed for a subset of the cohort by collecting air and water quality data alongside geographical, demographic and behavioural factors. Child development was assessed using neurodevelopmental assessments, home environment evaluation and quality of life measures. Biological samples were collected from mothers and children, processed promptly and biobanked locally. Sample data were entered into an OpenSpecimen database and linked to each individual, as well as to their corresponding social determinants and clinical data. Findings to date: A total of 2980 women and 2909 children completed at least one PRECISE-DYAD Study visit. The biorepository contains 108 897 biological samples from mothers and children. Baseline descriptive analysis of the cohort is reported here. Future plans: Analysis of data and samples will include biomarker studies, social determinants of health and epidemiological investigations. These analyses will explore how placenta-related complications and environmental exposures, such as nutrition and air quality, interact to shape maternal health, mental well-being, subsequent pregnancies and mother-child interaction, as well as child growth and neurodevelopment through early childhood. Additional work will examine the biological pathways linking these exposures to outcomes and the impacts of caring for children with moderate-to-severe disabilities on maternal well-being. Findings will be disseminated through scientific publications, conference presentations, engagement with local stakeholders and continued community outreach.
AB - Purpose: The PREgnancy Care Integrating Translational Science, Everywhere (PRECISE)-DYAD Study is a prospective observational cohort designed to investigate health outcomes among mother-child pairs (dyads) over the first 3 years of life in two contexts from sub-Saharan Africa. The primary objective of the study was to explore the effects of selected placenta-related complications, such as pregnancy hypertension, fetal growth restriction and preterm birth, on (1) Child health and development, and (2) Women’s health and well-being, including outcomes after stillbirth. Participants: The PRECISE-DYAD Study enrolled women (and their children) originally recruited into the PRECISE pregnancy cohort study in The Gambia and Kenya between July 2021 and April 2024. Participants were seen at 6 weeks to 6 months, 12 months, 24 months and 36 months postpartum. Clinical and health data, including anthropometry and diet, were collected for both mothers and children. Mother assessment included a cardiology assessment and collection of data about symptoms of COVID-19 infection. In a subset of participants, mothers were asked about their mental health, their healthcare costs during and after pregnancy, and experiences of care during labour and childbirth/delivery. Additionally, a personal environmental exposure assessment was performed for a subset of the cohort by collecting air and water quality data alongside geographical, demographic and behavioural factors. Child development was assessed using neurodevelopmental assessments, home environment evaluation and quality of life measures. Biological samples were collected from mothers and children, processed promptly and biobanked locally. Sample data were entered into an OpenSpecimen database and linked to each individual, as well as to their corresponding social determinants and clinical data. Findings to date: A total of 2980 women and 2909 children completed at least one PRECISE-DYAD Study visit. The biorepository contains 108 897 biological samples from mothers and children. Baseline descriptive analysis of the cohort is reported here. Future plans: Analysis of data and samples will include biomarker studies, social determinants of health and epidemiological investigations. These analyses will explore how placenta-related complications and environmental exposures, such as nutrition and air quality, interact to shape maternal health, mental well-being, subsequent pregnancies and mother-child interaction, as well as child growth and neurodevelopment through early childhood. Additional work will examine the biological pathways linking these exposures to outcomes and the impacts of caring for children with moderate-to-severe disabilities on maternal well-being. Findings will be disseminated through scientific publications, conference presentations, engagement with local stakeholders and continued community outreach.
KW - Child
KW - Mothers
KW - Observational Study
UR - https://www.scopus.com/pages/publications/105045214640
U2 - 10.1136/bmjopen-2025-115586
DO - 10.1136/bmjopen-2025-115586
M3 - Article
AN - SCOPUS:105045214640
SN - 2044-6055
VL - 16
JO - BMJ Open
JF - BMJ Open
IS - 7
M1 - e115586
ER -
SDG 3 Good Health and Well-being