Predictive accuracy of anti mullerian hormone as indicator of ovarian follicle loss in cyclophosphamide treated mice

Zehra Jamil; Khalida Perveen; Rabia Malik; Lubna Avesi

Predictive accuracy of anti mullerian hormone as indicator of ovarian follicle loss in cyclophosphamide treated mice

Zehra Jamil, Khalida Perveen, Rabia Malik, Lubna Avesi

Department of Biological & Biomedical Sciences, Medical College, Pakistan

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Abstract

Objective: To evaluate the strength of anti-mullerian hormone in reflecting the stages of ovarian toxicity-induced by cyclophosphamide.Methods: This study was conducted in December 2014 and comprised female mice that were divided into four groups: group A served as control, group B received three weekly injections of cyclophosphamide, group C was co administered alpha-tocopherol along with cyclophosphamide, while group D solely received alpha-tocopherol. The ovaries were evaluated for follicular dynamics, and anti-mullerian hormone was assessed using mouse enzyme-linked immunosorbent assay kit. The data was analysed using SPSS 19.Results: There were 40 mice in the study. Histological analysis revealed severely reduced ovarian reserve in group B(pConclusions: There was substantial evidence that anti-mullerian hormone monitoring during chemotherapy administration may fulfil the criteria of earliest diagnostic indicator of secondary infertility.

Original language	Undefined/Unknown
Journal	Department of Biological & Biomedical Sciences
Publication status	Published - 1 Oct 2017

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Predictive accuracy of anti mullerian hormone as indicator of ova

http://ecommons.aku.edu/pakistan_fhs_mc_bbs/777

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title = "Predictive accuracy of anti mullerian hormone as indicator of ovarian follicle loss in cyclophosphamide treated mice",

abstract = "Objective: To evaluate the strength of anti-mullerian hormone in reflecting the stages of ovarian toxicity-induced by cyclophosphamide.Methods: This study was conducted in December 2014 and comprised female mice that were divided into four groups: group A served as control, group B received three weekly injections of cyclophosphamide, group C was co administered alpha-tocopherol along with cyclophosphamide, while group D solely received alpha-tocopherol. The ovaries were evaluated for follicular dynamics, and anti-mullerian hormone was assessed using mouse enzyme-linked immunosorbent assay kit. The data was analysed using SPSS 19.Results: There were 40 mice in the study. Histological analysis revealed severely reduced ovarian reserve in group B(pConclusions: There was substantial evidence that anti-mullerian hormone monitoring during chemotherapy administration may fulfil the criteria of earliest diagnostic indicator of secondary infertility.",

author = "Zehra Jamil and Khalida Perveen and Rabia Malik and Lubna Avesi",

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T1 - Predictive accuracy of anti mullerian hormone as indicator of ovarian follicle loss in cyclophosphamide treated mice

AU - Jamil, Zehra

AU - Perveen, Khalida

AU - Malik, Rabia

AU - Avesi, Lubna

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Objective: To evaluate the strength of anti-mullerian hormone in reflecting the stages of ovarian toxicity-induced by cyclophosphamide.Methods: This study was conducted in December 2014 and comprised female mice that were divided into four groups: group A served as control, group B received three weekly injections of cyclophosphamide, group C was co administered alpha-tocopherol along with cyclophosphamide, while group D solely received alpha-tocopherol. The ovaries were evaluated for follicular dynamics, and anti-mullerian hormone was assessed using mouse enzyme-linked immunosorbent assay kit. The data was analysed using SPSS 19.Results: There were 40 mice in the study. Histological analysis revealed severely reduced ovarian reserve in group B(pConclusions: There was substantial evidence that anti-mullerian hormone monitoring during chemotherapy administration may fulfil the criteria of earliest diagnostic indicator of secondary infertility.

AB - Objective: To evaluate the strength of anti-mullerian hormone in reflecting the stages of ovarian toxicity-induced by cyclophosphamide.Methods: This study was conducted in December 2014 and comprised female mice that were divided into four groups: group A served as control, group B received three weekly injections of cyclophosphamide, group C was co administered alpha-tocopherol along with cyclophosphamide, while group D solely received alpha-tocopherol. The ovaries were evaluated for follicular dynamics, and anti-mullerian hormone was assessed using mouse enzyme-linked immunosorbent assay kit. The data was analysed using SPSS 19.Results: There were 40 mice in the study. Histological analysis revealed severely reduced ovarian reserve in group B(pConclusions: There was substantial evidence that anti-mullerian hormone monitoring during chemotherapy administration may fulfil the criteria of earliest diagnostic indicator of secondary infertility.

M3 - Article

JO - Department of Biological & Biomedical Sciences

JF - Department of Biological & Biomedical Sciences

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