Preeclampsia prediction with blood pressure measurements: A global external validation of the ALSPAC models

Annelien C. de Kat, Jane E. Hirst, Mark Woodward, Fernando C. Barros, Hellen C. Barsosio, James A. Berkley, Maria Carvalho, Leila Cheikh Ismail, Rose McGready, Shane A. Norris, Francois Nosten, Eric Ohuma, Chrystelle O.O. Tshivuila-Matala, William Stones, Eleonora Staines Urias, Maria Clara Restrepo-Mendez, Ann Lambert, Shama Munim, Adele Winsey, Aris T. PapageorghiouZulfiqar A. Bhutta, Jose Villar, Stephen H. Kennedy, Sanne A.E. Peters

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objective: The prediction of preeclampsia in pregnancy has resulted in a plethora of prognostic models. Yet, very few make it past the development stage and most fail to influence clinical practice. The timely identification of high-risk pregnant women could deliver a tailored antenatal care regimen, particularly in low-resource settings. This study externally validated and calibrated previously published models that predicted the risk of preeclampsia, based on blood pressure (BP) at multiple time points in pregnancy, in a geographically diverse population. Methods: The prospective INTERBIO-21st Fetal Study included 3,391 singleton pregnancies from Brazil, Kenya, Pakistan, South Africa, Thailand and the UK, 2012–2018. Preeclampsia prediction was based on baseline characteristics, BP and deviation from the expected BP trajectory at multiple time points in pregnancy. The prediction rules from the Avon Longitudinal Study of Parents and Children (ALSPAC) were implemented in the INTERBIO-21st cohort. Results: Model discrimination was similar to the development cohort. Performance was best with baseline characteristics and a BP measurement at 34 weeks’ gestation (AUC 0.85, 95 % CI 0.80–0.90). The ALSPAC models largely overestimated the true risk of preeclampsia incidence in the INTERBIO-21st cohort. Conclusions: After recalibration, these prediction models could potentially serve as a risk stratifying tool to help identify women who might benefit from increased surveillance during pregnancy.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalPregnancy Hypertension
Publication statusPublished - Dec 2022
Externally publishedYes


Dive into the research topics of 'Preeclampsia prediction with blood pressure measurements: A global external validation of the ALSPAC models'. Together they form a unique fingerprint.

Cite this