Pregnancy outcome and placental weights: their relationship to HIV-1 infection.

P. B. Gichangi, A. O. Nyongo, M. Temmerman

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The relationship between placental characteristics, including weight and inflammation, and pregnancy outcome was examined as part of a case control study looking into the impact of maternal HIV-1 infection on pregnancy outcome. Cases defined as low birth weight (< 2500g) or stillbirth deliveries, were compared to controls defined as mothers who delivered a live born neonate weighing 2500g or more. The mean placental weight and the mean foetal/placental weight ratio were significantly lower in cases (n = 253) than in controls (n = 216) (p < .05). Placental inflammation (chorioamnionitis) was significantly associated with prematurity (p < .001) and with stillbirth (p < .05), maternal HIV-1 antibody being a risk factor for chorioamnionitis in the preterm group. These data support a correlation between placental weight and pregnancy outcome, and suggest that maternal HIV-1 infection is a risk factor for chorioamnionitis in HIV-1 seropositive preterm deliveries.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalEast African Medical Journal
Issue number2
Publication statusPublished - Feb 1993
Externally publishedYes


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