Preparation of 188Re-lanreotide peptide and its quality control

A. Mushtaq; Shahid Pervez; I. Haider

doi:10.1524/ract.2000.88.8.495

Preparation of ¹⁸⁸Re-lanreotide peptide and its quality control

A. Mushtaq, Shahid Pervez, I. Haider

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

A simple method is described for the preparation of ¹⁸⁸Re-Lanreotide, a radiolabeled synthetic peptide derived from an analogue of somatostatin, using Lanreotide (50 µg) and stannous tartrate to which is added carrier-free ¹⁸⁸Re. The radiolabeling has been carried out with ∼555 MBq (15 mCi) with a >95% labeling efficiency and no need for subsequent purification. ITLC and HPLC techniques were employed for monitoring the stability and labeling yield. Radiolabeling results in one major peak when analyzed by reverse-phase (RP) HPLC.

Original language	English
Pages (from-to)	495-498
Number of pages	4
Journal	Radiochimica Acta
Volume	88
Issue number	36739
DOIs	https://doi.org/10.1524/ract.2000.88.8.495
Publication status	Published - 2000
Externally published	Yes

Keywords

Direct labeling
Lanreotide
Rhenium-188
Somatostatin analog
Transchelating agent

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10.1524/ract.2000.88.8.495

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abstract = "A simple method is described for the preparation of 188Re-Lanreotide, a radiolabeled synthetic peptide derived from an analogue of somatostatin, using Lanreotide (50 µg) and stannous tartrate to which is added carrier-free 188Re. The radiolabeling has been carried out with ∼555 MBq (15 mCi) with a >95% labeling efficiency and no need for subsequent purification. ITLC and HPLC techniques were employed for monitoring the stability and labeling yield. Radiolabeling results in one major peak when analyzed by reverse-phase (RP) HPLC.",

keywords = "Direct labeling, Lanreotide, Rhenium-188, Somatostatin analog, Transchelating agent",

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AU - Mushtaq, A.

AU - Pervez, Shahid

AU - Haider, I.

PY - 2000

Y1 - 2000

N2 - A simple method is described for the preparation of 188Re-Lanreotide, a radiolabeled synthetic peptide derived from an analogue of somatostatin, using Lanreotide (50 µg) and stannous tartrate to which is added carrier-free 188Re. The radiolabeling has been carried out with ∼555 MBq (15 mCi) with a >95% labeling efficiency and no need for subsequent purification. ITLC and HPLC techniques were employed for monitoring the stability and labeling yield. Radiolabeling results in one major peak when analyzed by reverse-phase (RP) HPLC.

AB - A simple method is described for the preparation of 188Re-Lanreotide, a radiolabeled synthetic peptide derived from an analogue of somatostatin, using Lanreotide (50 µg) and stannous tartrate to which is added carrier-free 188Re. The radiolabeling has been carried out with ∼555 MBq (15 mCi) with a >95% labeling efficiency and no need for subsequent purification. ITLC and HPLC techniques were employed for monitoring the stability and labeling yield. Radiolabeling results in one major peak when analyzed by reverse-phase (RP) HPLC.

KW - Direct labeling

KW - Lanreotide

KW - Rhenium-188

KW - Somatostatin analog

KW - Transchelating agent

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M3 - Article

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SN - 0033-8230

VL - 88

SP - 495

EP - 498

JO - Radiochimica Acta

JF - Radiochimica Acta

IS - 36739

ER -

Preparation of ¹⁸⁸Re-lanreotide peptide and its quality control

Abstract

Keywords

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