TY - JOUR
T1 - Preparation, quality control and stability of 131I-Lanreotide
AU - Pervez, Shahid
AU - Mushtaq, A.
PY - 2005/11
Y1 - 2005/11
N2 - Lanreotide, a synthetic octapeptide analog of a native hormone somatostatin, was labeled with 131I, the most widely used therapeutic and easily available radionuclide. Radioiodination of Lanreotide was carried out by Chloramine-T and Iodogen methods. Chloramine-T and Iodogen were used as oxidizing agents to form an electrophilic iodine species, which then labeled the tyrosine of Lanreotide. The maximum radiolabeling yield was ∼80%. Chloramine-T was found more suitable than the Iodogen method, because nearly 25% of the initial iodine activity was lost/adsorbed on the Iodogen coating. Thin layer and high performance liquid chromatographies were used for monitoring the reaction of 131I with Lanreotide, the stability and purity of 131I-Lanreotide.
AB - Lanreotide, a synthetic octapeptide analog of a native hormone somatostatin, was labeled with 131I, the most widely used therapeutic and easily available radionuclide. Radioiodination of Lanreotide was carried out by Chloramine-T and Iodogen methods. Chloramine-T and Iodogen were used as oxidizing agents to form an electrophilic iodine species, which then labeled the tyrosine of Lanreotide. The maximum radiolabeling yield was ∼80%. Chloramine-T was found more suitable than the Iodogen method, because nearly 25% of the initial iodine activity was lost/adsorbed on the Iodogen coating. Thin layer and high performance liquid chromatographies were used for monitoring the reaction of 131I with Lanreotide, the stability and purity of 131I-Lanreotide.
UR - http://www.scopus.com/inward/record.url?scp=26444455579&partnerID=8YFLogxK
U2 - 10.1007/s10967-005-0902-7
DO - 10.1007/s10967-005-0902-7
M3 - Article
AN - SCOPUS:26444455579
SN - 0236-5731
VL - 266
SP - 265
EP - 268
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
IS - 2
ER -
