TY - JOUR
T1 - Prevalence and Missed Cases of Respiratory Distress Syndrome Disease Amongst Neonatal Deaths Enrolled in the Kenya Child Health and Mortality Prevention Surveillance Network (CHAMPS) Program Between 2017 and 2021
AU - Owuor, Harun O.
AU - Akelo, Victor
AU - Murila, Florence
AU - Onyango, Dickens
AU - Kuria, Magdalene
AU - Rogena, Emily
AU - Revathi, Gunturu
AU - Mitei, Paul
AU - Sava, Solomon
AU - Were, Joyce
AU - Igunza, Aggrey
AU - Khagayi, Sammy
AU - Zielinski-Gutierrez, Emily
AU - Hawi, Sarah
AU - Gethi, Dickson
AU - Verani, Jennifer R.
AU - Onyango, Clayton
AU - Blau, Dianna M.
AU - Tippett Barr, Beth A.
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Objectives. To describe RDS in neonatal deaths at the CHAMPS-Kenya site between 2017 and 2021. Methods. We included 165 neonatal deaths whose their Causes of death (COD) were determined by a panel of experts using data from post-mortem conducted through minimally invasive tissue specimen testing, clinical records, and verbal autopsy. Results. Twenty-six percent (43/165) of neonatal deaths were attributable to RDS. Most cases occurred in low birthweight and preterm neonates. From these cases, less than half of the hospitalizations were diagnosed with RDS before death, and essential diagnostic tests were not performed in most cases. Most cases received suboptimal levels of supplemental oxygen, and critical interventions like surfactant replacement therapy and mechanical ventilation were not adequately utilized when available. Conclusion. The study highlights the urgent need for improved diagnosis and management of RDS, emphasizing the importance of increasing clinical suspicion and enhancing training in its clinical management to reduce mortality rates.
AB - Objectives. To describe RDS in neonatal deaths at the CHAMPS-Kenya site between 2017 and 2021. Methods. We included 165 neonatal deaths whose their Causes of death (COD) were determined by a panel of experts using data from post-mortem conducted through minimally invasive tissue specimen testing, clinical records, and verbal autopsy. Results. Twenty-six percent (43/165) of neonatal deaths were attributable to RDS. Most cases occurred in low birthweight and preterm neonates. From these cases, less than half of the hospitalizations were diagnosed with RDS before death, and essential diagnostic tests were not performed in most cases. Most cases received suboptimal levels of supplemental oxygen, and critical interventions like surfactant replacement therapy and mechanical ventilation were not adequately utilized when available. Conclusion. The study highlights the urgent need for improved diagnosis and management of RDS, emphasizing the importance of increasing clinical suspicion and enhancing training in its clinical management to reduce mortality rates.
KW - histopathological presentation
KW - low and middle-income countries
KW - neonatal mortality
KW - respiratory distress syndrome
UR - http://www.scopus.com/inward/record.url?scp=85179176740&partnerID=8YFLogxK
U2 - 10.1177/2333794X231212819
DO - 10.1177/2333794X231212819
M3 - Article
AN - SCOPUS:85179176740
SN - 2333-794X
VL - 10
JO - Global Pediatric Health
JF - Global Pediatric Health
ER -