TY - JOUR
T1 - Prevalence and significance of vitamin D deficiency and insufficiency among apparently healthy adults
AU - Mansoor, Shireen
AU - Habib, Aysha
AU - Ghani, Farooq
AU - Fatmi, Zafar
AU - Badruddin, Salma
AU - Mansoor, Sarwat
AU - Siddiqui, Imran
AU - Jabbar, Abdul
PY - 2010/12
Y1 - 2010/12
N2 - Objective: This study aims to determine the prevalence and significance of vitamin D deficiency and insufficiency among apparently healthy adults. Design and methods: A total of 123 subjects, 56.9% males and 43.1% females, were recruited from a tertiary care hospital in Karachi, Pakistan. Questionnaires were administered to gather demographics; height, weight, and blood samples were also taken. For staging serum 25OHD, the cutoff values ≤50. nmol/L and 50.1-74.9. nmol/L were defined as deficiency and insufficiency, respectively. Results: The mean vitamin D level in the study subjects was 41.1 ±9.6. nmol/L. Of them, 90% had low serum 25OHD levels: 69.9% were deficient and 21.1% had insufficient levels of 25OHD. There was a significant negative correlation between serum 25OHD and iPTH levels. Conclusion: The high prevalence of vitamin D deficiency and insufficiency showed that a high proportion of apparently healthy adults are at risk of developing musculoskeletal and other chronic diseases. Serum iPTH and serum 25OHD levels are better markers of this deficiency as compared to other markers.
AB - Objective: This study aims to determine the prevalence and significance of vitamin D deficiency and insufficiency among apparently healthy adults. Design and methods: A total of 123 subjects, 56.9% males and 43.1% females, were recruited from a tertiary care hospital in Karachi, Pakistan. Questionnaires were administered to gather demographics; height, weight, and blood samples were also taken. For staging serum 25OHD, the cutoff values ≤50. nmol/L and 50.1-74.9. nmol/L were defined as deficiency and insufficiency, respectively. Results: The mean vitamin D level in the study subjects was 41.1 ±9.6. nmol/L. Of them, 90% had low serum 25OHD levels: 69.9% were deficient and 21.1% had insufficient levels of 25OHD. There was a significant negative correlation between serum 25OHD and iPTH levels. Conclusion: The high prevalence of vitamin D deficiency and insufficiency showed that a high proportion of apparently healthy adults are at risk of developing musculoskeletal and other chronic diseases. Serum iPTH and serum 25OHD levels are better markers of this deficiency as compared to other markers.
KW - Adult
KW - Chronic disease
KW - Musculoskeletal disease
KW - Prevalence
KW - Vitamin D deficiency
UR - http://www.scopus.com/inward/record.url?scp=78149500207&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2010.09.022
DO - 10.1016/j.clinbiochem.2010.09.022
M3 - Article
C2 - 20875809
AN - SCOPUS:78149500207
SN - 0009-9120
VL - 43
SP - 1431
EP - 1435
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 18
ER -