Abstract
Objective: To determine the type of prevalent aerobic gram-negative bacilli and their sensitivity pattern among nosocomial isolates. Design: Prospective collection of clinically significant nosocomial gram negative bacilli. Setting: Tertiary care hospital in Karachi. Method: One hundred isolates were identified by standard methods and minimum inhibitory concentration was checked by epsilometer test. Results: The most frequent isolates were Eschericia coli (43%) followed by Klebsiella pneumoniae (18%) Acinetobacter spp. (7%) Enterobacter spp. (7%) and Klebsiella spp. other than pneumoniae (7%). Most of the isolates of dominant species (E.coli and Klebsiella pneumoniae) were multiresistant including third generation cephalosporins. Conclusion: This study indicates that most effective antibiotics imipenem and amikacin inhibited most of the isolates. Imipenem alone or amikacin in combination with one broad spectrum β-lactam drug should be used in initial empiric therapy in any life threatening nosocomial infection.
Original language | English |
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Pages (from-to) | 169-172 |
Number of pages | 4 |
Journal | Journal of the Pakistan Medical Association |
Volume | 49 |
Issue number | 7 |
Publication status | Published - 1999 |
Externally published | Yes |