Prevalent nosocomial gram negative aerobic bacilli and their antimicrobial susceptibility pattern in intensive care unit

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Abstract

Objective: To determine the type of prevalent aerobic gram-negative bacilli and their sensitivity pattern among nosocomial isolates. Design: Prospective collection of clinically significant nosocomial gram negative bacilli. Setting: Tertiary care hospital in Karachi. Method: One hundred isolates were identified by standard methods and minimum inhibitory concentration was checked by epsilometer test. Results: The most frequent isolates were Eschericia coli (43%) followed by Klebsiella pneumoniae (18%) Acinetobacter spp. (7%) Enterobacter spp. (7%) and Klebsiella spp. other than pneumoniae (7%). Most of the isolates of dominant species (E.coli and Klebsiella pneumoniae) were multiresistant including third generation cephalosporins. Conclusion: This study indicates that most effective antibiotics imipenem and amikacin inhibited most of the isolates. Imipenem alone or amikacin in combination with one broad spectrum β-lactam drug should be used in initial empiric therapy in any life threatening nosocomial infection.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalJournal of the Pakistan Medical Association
Volume49
Issue number7
Publication statusPublished - 1999
Externally publishedYes

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