Primary amoebic meningoencephalitis: Two new cases from Pakistan

Taimur Saleem, Madiha Rabbani, Bushra Jamil

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11 Citations (Scopus)

Abstract

Naegleria fowleri causes a fatal infection of the central nervous system. Only one case of N. fowleri meningoencephalitis has previously been reported from Pakistan. We describe two cases of primary amoebic meningoencephalitis. A 24-year-old man presented with a two-day history of high grade fever, headaches and vomiting. He was put on intrathecal amphotericin B, fluconazole and rifampicin when motile trophozoites were identified on a wet mount of cerebrospinal fluid. The patient did not improve and died on the sixth day of admission. The second case was a 30-year-old man who presented with a three-day history of high grade fever, vomiting and agitation. His clinical course was marked by a rapid deterioration. He received intrathecal amphotericin B, fluconazole and broad spectrum antibiotics when motile trophozoites on wet mount were observed. Again, the patient's condition did not improve and he died on the eighth day of admission.

Original languageEnglish
Pages (from-to)242-243
Number of pages2
JournalTropical Doctor
Volume39
Issue number4
DOIs
Publication statusPublished - Oct 2009

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