TY - JOUR
T1 - Probable chromosomal mutation to resistance to all aminoglycosides in staphylococcus aureus selected by the therapeutic use of gentamicin
T2 - A preliminary report
AU - Heritage, John
AU - Settle, John A.D.
AU - Lalani, El Nasir M.A.
AU - Lacey, Richard W.
PY - 1986/5
Y1 - 1986/5
N2 - A patient suffering from burns was treated with gentamicin: subsequently, a 'methicillin-resistant' strain of Staphylococcus aureus (B27), was isolated which was highly resistant to this antibiotic and all other aminoglycosides. In all other respects this isolate resembled the gentamicin-sensitive 'methicillin-resistant' S. aureus prevalent on the Yorkshire Regional Burns Unit. Subsequently, fusidic acid treatment was substituted for gentamicin therapy, and a fusidic acid-resistant variant was isolated from the same patient. This article reports a preliminary characterization of these isolates.
AB - A patient suffering from burns was treated with gentamicin: subsequently, a 'methicillin-resistant' strain of Staphylococcus aureus (B27), was isolated which was highly resistant to this antibiotic and all other aminoglycosides. In all other respects this isolate resembled the gentamicin-sensitive 'methicillin-resistant' S. aureus prevalent on the Yorkshire Regional Burns Unit. Subsequently, fusidic acid treatment was substituted for gentamicin therapy, and a fusidic acid-resistant variant was isolated from the same patient. This article reports a preliminary characterization of these isolates.
UR - http://www.scopus.com/inward/record.url?scp=0022636488&partnerID=8YFLogxK
U2 - 10.1093/jac/17.5.571
DO - 10.1093/jac/17.5.571
M3 - Article
C2 - 3636322
AN - SCOPUS:0022636488
SN - 0305-7453
VL - 17
SP - 571
EP - 574
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
IS - 5
ER -
