Probable chromosomal mutation to resistance to all aminoglycosides in staphylococcus aureus selected by the therapeutic use of gentamicin: A preliminary report

John Heritage; John A.D. Settle; El Nasir M.A. Lalani; Richard W. Lacey

doi:10.1093/jac/17.5.571

Probable chromosomal mutation to resistance to all aminoglycosides in staphylococcus aureus selected by the therapeutic use of gentamicin: A preliminary report

John Heritage
, John A.D. Settle
, El Nasir M.A. Lalani
, Richard W. Lacey

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A patient suffering from burns was treated with gentamicin: subsequently, a 'methicillin-resistant' strain of Staphylococcus aureus (B27), was isolated which was highly resistant to this antibiotic and all other aminoglycosides. In all other respects this isolate resembled the gentamicin-sensitive 'methicillin-resistant' S. aureus prevalent on the Yorkshire Regional Burns Unit. Subsequently, fusidic acid treatment was substituted for gentamicin therapy, and a fusidic acid-resistant variant was isolated from the same patient. This article reports a preliminary characterization of these isolates.

Original language	English (UK)
Pages (from-to)	571-574
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	17
Issue number	5
DOIs	https://doi.org/10.1093/jac/17.5.571
Publication status	Published - May 1986
Externally published	Yes

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10.1093/jac/17.5.571

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title = "Probable chromosomal mutation to resistance to all aminoglycosides in staphylococcus aureus selected by the therapeutic use of gentamicin: A preliminary report",

abstract = "A patient suffering from burns was treated with gentamicin: subsequently, a 'methicillin-resistant' strain of Staphylococcus aureus (B27), was isolated which was highly resistant to this antibiotic and all other aminoglycosides. In all other respects this isolate resembled the gentamicin-sensitive 'methicillin-resistant' S. aureus prevalent on the Yorkshire Regional Burns Unit. Subsequently, fusidic acid treatment was substituted for gentamicin therapy, and a fusidic acid-resistant variant was isolated from the same patient. This article reports a preliminary characterization of these isolates.",

author = "John Heritage and Settle, \{John A.D.\} and Lalani, \{El Nasir M.A.\} and Lacey, \{Richard W.\}",

year = "1986",

month = may,

doi = "10.1093/jac/17.5.571",

language = "English (UK)",

volume = "17",

pages = "571--574",

journal = "Journal of Antimicrobial Chemotherapy",

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publisher = "Oxford University Press",

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}

Probable chromosomal mutation to resistance to all aminoglycosides in staphylococcus aureus selected by the therapeutic use of gentamicin: A preliminary report. / Heritage, John; Settle, John A.D.; Lalani, El Nasir M.A. et al.
In: Journal of Antimicrobial Chemotherapy, Vol. 17, No. 5, 05.1986, p. 571-574.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Probable chromosomal mutation to resistance to all aminoglycosides in staphylococcus aureus selected by the therapeutic use of gentamicin

T2 - A preliminary report

AU - Heritage, John

AU - Settle, John A.D.

AU - Lalani, El Nasir M.A.

AU - Lacey, Richard W.

PY - 1986/5

Y1 - 1986/5

N2 - A patient suffering from burns was treated with gentamicin: subsequently, a 'methicillin-resistant' strain of Staphylococcus aureus (B27), was isolated which was highly resistant to this antibiotic and all other aminoglycosides. In all other respects this isolate resembled the gentamicin-sensitive 'methicillin-resistant' S. aureus prevalent on the Yorkshire Regional Burns Unit. Subsequently, fusidic acid treatment was substituted for gentamicin therapy, and a fusidic acid-resistant variant was isolated from the same patient. This article reports a preliminary characterization of these isolates.

AB - A patient suffering from burns was treated with gentamicin: subsequently, a 'methicillin-resistant' strain of Staphylococcus aureus (B27), was isolated which was highly resistant to this antibiotic and all other aminoglycosides. In all other respects this isolate resembled the gentamicin-sensitive 'methicillin-resistant' S. aureus prevalent on the Yorkshire Regional Burns Unit. Subsequently, fusidic acid treatment was substituted for gentamicin therapy, and a fusidic acid-resistant variant was isolated from the same patient. This article reports a preliminary characterization of these isolates.

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U2 - 10.1093/jac/17.5.571

DO - 10.1093/jac/17.5.571

M3 - Article

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AN - SCOPUS:0022636488

SN - 0305-7453

VL - 17

SP - 571

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 5

ER -

Probable chromosomal mutation to resistance to all aminoglycosides in staphylococcus aureus selected by the therapeutic use of gentamicin: A preliminary report

Abstract

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