Prognostic markers in chronic lymphocytic leukaemia - A flow cytometric analysis

Hala Haq, Nasir Uddin, Saleemahmed Khan, Sunia Ghaffar

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objective: To find out the frequency of ZAP-70, CD38 and CD49d in patients diagnosed with CLL in our population. Methods: This is a cross sectional study conducted in Army Medical College in collaboration with Armed Forces Institute of Pathology and Military Hospital Rawalpindi from 1st January 2018 to 30th November 2018. Permission from Institutional Ethical Committee was obtained. Blood samples were collected by non-probability consecutive sampling technique and analyzed for blood counts and flow cytometry was done for ZAP-70, CD38 and CD49d. Manufacturer’s instructions for the kits were strictly followed. Results: Fifty-one newly diagnosed patients with CLL were studied for the prognostic markers in CLL. CD 38 was expressed in 25(49%) and CD49d in 21(41.2%). ZAP-70 expression was not detected in our series of patients. Conclusion: We conclude that CD38 and CD49d expression was detected in almost half of the patients of CLL in our series. CD49d showed statistically positive correlation with CD38, showing that it is a more pragmatic choice for reliable prognostication of CLL along with CD38.

Original languageEnglish
JournalPakistan Journal of Medical Sciences
Issue number3
Publication statusPublished - 2020
Externally publishedYes


  • CD39
  • CD49d
  • Chronic Lymphocytic Leukaemia
  • Immunophenotyping
  • Prognostic markers
  • ZAP-70


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