Prolactin and neuroleptic drugs: A biochemical index of clinical response?

Z. Merali, Y. D. Lapierre

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Elevation of serum prolaction in response to pipothiazine was of a greater magnitude than that following administration of fluphenazine decanoate. Females weremore sensitive to the neuroleptic-induced disinhibition of prolactin release than their male counterparts. In contrast to reports on short-acting neuroleptics, a ceiling effect on prolactin elevation was not observed when therapeutically effective dosages of long-acting preparations were used. A overall curvilinear relationship between symptoms and prolactin change was observed. The predicted negative relationship between clinical response and prolactin was clearly evident mainly in females on pipothiazine palmitate.

Original languageEnglish
Pages (from-to)140-161
Number of pages22
JournalInternational Journal of Mental Health
Issue number3-4
Publication statusPublished - 1980
Externally publishedYes


Dive into the research topics of 'Prolactin and neuroleptic drugs: A biochemical index of clinical response?'. Together they form a unique fingerprint.

Cite this