Abstract
Three patients who were treated with repetitive courses of high‐dose methotrexate and leucovorin rescue experienced hypersensitivity symptoms during infusion of the drug. Serum from all three patients contained one complex of methotrexate bound to a protein similar in size to albumin and a second complex of the protein‐bound methotrexate coupled to IgG. This immune complex was not found in 4 patients similarly treated who did not experience hypersensitivity symptoms. Cancer 46:471–474, 1980.
Original language | English |
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Pages (from-to) | 471-474 |
Number of pages | 4 |
Journal | Cancer |
Volume | 46 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Aug 1980 |
Externally published | Yes |