Protein‐methotrexate‐IgG complexes in the serum of patients receiving high‐dose antifolate therapy

Maria Da Costa, William Isacoff, Sheldon P. Rothenberg, M. Perwaiz Iqbal

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Three patients who were treated with repetitive courses of high‐dose methotrexate and leucovorin rescue experienced hypersensitivity symptoms during infusion of the drug. Serum from all three patients contained one complex of methotrexate bound to a protein similar in size to albumin and a second complex of the protein‐bound methotrexate coupled to IgG. This immune complex was not found in 4 patients similarly treated who did not experience hypersensitivity symptoms. Cancer 46:471–474, 1980.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalCancer
Volume46
Issue number3
DOIs
Publication statusPublished - 1 Aug 1980
Externally publishedYes

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