Protein‐methotrexate‐IgG complexes in the serum of patients receiving high‐dose antifolate therapy

Maria Da Costa; William Isacoff; Sheldon P. Rothenberg; M. Perwaiz Iqbal

doi:10.1002/1097-0142(19800801)46:3<471::AID-CNCR2820460309>3.0.CO;2-O

Protein‐methotrexate‐IgG complexes in the serum of patients receiving high‐dose antifolate therapy

Maria Da Costa
, William Isacoff
, Sheldon P. Rothenberg
, M. Perwaiz Iqbal

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Three patients who were treated with repetitive courses of high‐dose methotrexate and leucovorin rescue experienced hypersensitivity symptoms during infusion of the drug. Serum from all three patients contained one complex of methotrexate bound to a protein similar in size to albumin and a second complex of the protein‐bound methotrexate coupled to IgG. This immune complex was not found in 4 patients similarly treated who did not experience hypersensitivity symptoms. Cancer 46:471–474, 1980.

Original language	English (UK)
Pages (from-to)	471-474
Number of pages	4
Journal	Cancer
Volume	46
Issue number	3
DOIs	https://doi.org/10.1002/1097-0142(19800801)46:3<471::AID-CNCR2820460309>3.0.CO;2-O
Publication status	Published - 1 Aug 1980
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1002/1097-0142(19800801)46:3<471::AID-CNCR2820460309>3.0.CO;2-O

Cite this

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title = "Protein‐methotrexate‐IgG complexes in the serum of patients receiving high‐dose antifolate therapy",

abstract = "Three patients who were treated with repetitive courses of high‐dose methotrexate and leucovorin rescue experienced hypersensitivity symptoms during infusion of the drug. Serum from all three patients contained one complex of methotrexate bound to a protein similar in size to albumin and a second complex of the protein‐bound methotrexate coupled to IgG. This immune complex was not found in 4 patients similarly treated who did not experience hypersensitivity symptoms. Cancer 46:471–474, 1980.",

author = "Costa, \{Maria Da\} and William Isacoff and Rothenberg, \{Sheldon P.\} and Iqbal, \{M. Perwaiz\}",

year = "1980",

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doi = "10.1002/1097-0142(19800801)46:3<471::AID-CNCR2820460309>3.0.CO;2-O",

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T1 - Protein‐methotrexate‐IgG complexes in the serum of patients receiving high‐dose antifolate therapy

AU - Costa, Maria Da

AU - Isacoff, William

AU - Rothenberg, Sheldon P.

AU - Iqbal, M. Perwaiz

PY - 1980/8/1

Y1 - 1980/8/1

N2 - Three patients who were treated with repetitive courses of high‐dose methotrexate and leucovorin rescue experienced hypersensitivity symptoms during infusion of the drug. Serum from all three patients contained one complex of methotrexate bound to a protein similar in size to albumin and a second complex of the protein‐bound methotrexate coupled to IgG. This immune complex was not found in 4 patients similarly treated who did not experience hypersensitivity symptoms. Cancer 46:471–474, 1980.

AB - Three patients who were treated with repetitive courses of high‐dose methotrexate and leucovorin rescue experienced hypersensitivity symptoms during infusion of the drug. Serum from all three patients contained one complex of methotrexate bound to a protein similar in size to albumin and a second complex of the protein‐bound methotrexate coupled to IgG. This immune complex was not found in 4 patients similarly treated who did not experience hypersensitivity symptoms. Cancer 46:471–474, 1980.

UR - https://www.scopus.com/pages/publications/0018946162

U2 - 10.1002/1097-0142(19800801)46:3<471::AID-CNCR2820460309>3.0.CO;2-O

DO - 10.1002/1097-0142(19800801)46:3<471::AID-CNCR2820460309>3.0.CO;2-O

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AN - SCOPUS:0018946162

SN - 0008-543X

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SP - 471

EP - 474

JO - Cancer

JF - Cancer

IS - 3

ER -

Protein‐methotrexate‐IgG complexes in the serum of patients receiving high‐dose antifolate therapy

Abstract

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