TY - JOUR
T1 - Pseudoexfoliation in the Reykjavik Eye Study
T2 - Prevalence and related ophthalmological variables
AU - Arnarsson, Arsaell
AU - Damji, Karim F.
AU - Sverrisson, Thordur
AU - Sasaki, Hiroshi
AU - Jonasson, Fridbert
PY - 2007/12
Y1 - 2007/12
N2 - Purpose: To examine the age and sex-specific prevalence of pseudoexfoliation syndrome (PEX) and its relationship with some ophthalmological variables. Methods: We carried out a population-based study using a random sample taken from the national population census for citizens of Reykjavik, aged ≥ 50 years. A total of 1045 individuals participated in all parts of the study. Pseudoexfoliation was established by slit-lamp examination with a maximally dilated pupil carried out by two experienced ophthalmologists, who were masked to one another's results except in cases of disagreement where they had to reach a consensus. Results: In all, 108 (10.7%) persons were found to have PEX in at least one eye. Prevalence increased from 2.5% in those aged 50-59 years to 40.6% in those aged ≥ 80 years. Women were more frequently affected than men (12.3% versus 8.7%). This difference remained statistically significant after controlling for the effect of age (p < 0.001). Eyes with PEX were found to have higher intraocular pressure (IOP) than eyes without PEX (p < 0.05). However, PEX was not found to be related to central corneal thickness, anterior chamber depth, lens thickness, nuclear lens opacifications or optic disc morphology in a multivariate model. Comclusion: Pseudoexfoliation is an age-related phenomenon commonly found in Iceland. It is more commonly found in women than in men and is associated with elevated IOP.
AB - Purpose: To examine the age and sex-specific prevalence of pseudoexfoliation syndrome (PEX) and its relationship with some ophthalmological variables. Methods: We carried out a population-based study using a random sample taken from the national population census for citizens of Reykjavik, aged ≥ 50 years. A total of 1045 individuals participated in all parts of the study. Pseudoexfoliation was established by slit-lamp examination with a maximally dilated pupil carried out by two experienced ophthalmologists, who were masked to one another's results except in cases of disagreement where they had to reach a consensus. Results: In all, 108 (10.7%) persons were found to have PEX in at least one eye. Prevalence increased from 2.5% in those aged 50-59 years to 40.6% in those aged ≥ 80 years. Women were more frequently affected than men (12.3% versus 8.7%). This difference remained statistically significant after controlling for the effect of age (p < 0.001). Eyes with PEX were found to have higher intraocular pressure (IOP) than eyes without PEX (p < 0.05). However, PEX was not found to be related to central corneal thickness, anterior chamber depth, lens thickness, nuclear lens opacifications or optic disc morphology in a multivariate model. Comclusion: Pseudoexfoliation is an age-related phenomenon commonly found in Iceland. It is more commonly found in women than in men and is associated with elevated IOP.
KW - Anterior chamber depth
KW - Central corneal thickness
KW - Epidemiology
KW - Exfoliation
KW - Glaucoma
KW - Pseudoexfoliation
UR - http://www.scopus.com/inward/record.url?scp=36348957976&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0420.2007.01051.x
DO - 10.1111/j.1600-0420.2007.01051.x
M3 - Article
C2 - 18028119
AN - SCOPUS:36348957976
SN - 1395-3907
VL - 85
SP - 822
EP - 827
JO - Acta Ophthalmologica Scandinavica
JF - Acta Ophthalmologica Scandinavica
IS - 8
ER -