Pseudoexfoliation in the Reykjavik Eye Study: Prevalence and related ophthalmological variables

Arsaell Arnarsson, Karim F. Damji, Thordur Sverrisson, Hiroshi Sasaki, Fridbert Jonasson

Research output: Contribution to journalArticlepeer-review

124 Citations (Scopus)

Abstract

Purpose: To examine the age and sex-specific prevalence of pseudoexfoliation syndrome (PEX) and its relationship with some ophthalmological variables. Methods: We carried out a population-based study using a random sample taken from the national population census for citizens of Reykjavik, aged ≥ 50 years. A total of 1045 individuals participated in all parts of the study. Pseudoexfoliation was established by slit-lamp examination with a maximally dilated pupil carried out by two experienced ophthalmologists, who were masked to one another's results except in cases of disagreement where they had to reach a consensus. Results: In all, 108 (10.7%) persons were found to have PEX in at least one eye. Prevalence increased from 2.5% in those aged 50-59 years to 40.6% in those aged ≥ 80 years. Women were more frequently affected than men (12.3% versus 8.7%). This difference remained statistically significant after controlling for the effect of age (p < 0.001). Eyes with PEX were found to have higher intraocular pressure (IOP) than eyes without PEX (p < 0.05). However, PEX was not found to be related to central corneal thickness, anterior chamber depth, lens thickness, nuclear lens opacifications or optic disc morphology in a multivariate model. Comclusion: Pseudoexfoliation is an age-related phenomenon commonly found in Iceland. It is more commonly found in women than in men and is associated with elevated IOP.

Original languageEnglish
Pages (from-to)822-827
Number of pages6
JournalActa Ophthalmologica Scandinavica
Volume85
Issue number8
DOIs
Publication statusPublished - Dec 2007
Externally publishedYes

Keywords

  • Anterior chamber depth
  • Central corneal thickness
  • Epidemiology
  • Exfoliation
  • Glaucoma
  • Pseudoexfoliation

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