Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: Mouse strain-dependent outcomes

Hymie Anisman, Shawn Hayley, Owen Kelly, Thomas Borowski, Zul Merali

Research output: Contribution to journalArticlepeer-review

173 Citations (Scopus)

Abstract

The effects of several stressors were assessed in inbred strains of mice, BALB/cByJ and C57BL/6ByJ, thought to be differentially reactive to stressors. Behavioral reactivity was greater in BALB/cByJ mice with respect to open-field emergence, step-down responding, response to a predator (rat) or to fox urine odor. Neurogenic insults (e.g., footshock, forced swim, restraint) and a systemic stressor (intraperitoneal interleukin-1β treatment) likewise provoked a greater rise of plasma corticosterone in the BALB/cByJ mice. Psychogenic stressors (e.g., novel open-field exposure, acoustic startle stimuli) also enhanced plasma corticosterone to a greater extent in BALB/cByJ mice, but such an outcome was not apparent following predator-related cues. It appears that whereas stressor reactivity and adrenal glucocorticoid release may be exaggerated in BALB/cByJ mice, such effects may be dependent on the specific characteristic of the stressor situation.

Original languageEnglish
Pages (from-to)443-454
Number of pages12
JournalBehavioral Neuroscience
Volume115
Issue number2
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Dive into the research topics of 'Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: Mouse strain-dependent outcomes'. Together they form a unique fingerprint.

Cite this