Pulmonary Tuberculosis in Severely Malnourished Children Admitted to Nutrition Rehabilitation Centers: A Multicenter Study

NRC Group

doi:10.1007/s12098-023-04723-5

Pulmonary Tuberculosis in Severely Malnourished Children Admitted to Nutrition Rehabilitation Centers: A Multicenter Study

NRC Group

Department of Surgery, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To identify prevalence of pulmonary tuberculosis (TB) in severely malnourished children admitted to nutritional rehabilitation centers. Methods: A multicenter cross-sectional study involving 41 nutrition rehabilitation centres (NRCs) across India was carried out to document prevalence of pulmonary tuberculosis in acute severe malnourished children admitted in NRCs. After training of the NRC staff to follow algorithm provided by national tuberculosis elimination program, children admitted to NRCs were screened for pulmonary tuberculosis. Results: A total of 4356 children were enrolled across all the sites. Gastric aspirate for Cartridge based nucleic acid amplification test (CBNAAT), tuberculin skin test (TST) and X-ray film of chest were done in more than 99% of enrolled subjects. A total of 189 children (4.3%) had pulmonary tuberculosis. Eighty-seven (1.99%) were microbiologically confirmed by positive CBNAAT. On multivariate analysis, only significant association was with history of contact with TB patient in family. Conclusions: The present results suggest that a significant proportion (>4%) of children admitted in NRCs suffer from pulmonary tuberculosis. It is feasible to improve diagnosis of tuberculosis as a whole and microbiologically confirmed TB.

Original language	English
Journal	Indian Journal of Pediatrics
DOIs	https://doi.org/10.1007/s12098-023-04723-5
Publication status	Accepted/In press - 2023

Keywords

CBNAAT
Gastric lavage
Nutritional rehabilitation center
TrueNat
Tuberculin skin test

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12098-023-04723-5

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@article{a6b53d83636b4f5f838f76c400f2cd76,

title = "Pulmonary Tuberculosis in Severely Malnourished Children Admitted to Nutrition Rehabilitation Centers: A Multicenter Study",

abstract = "Objectives: To identify prevalence of pulmonary tuberculosis (TB) in severely malnourished children admitted to nutritional rehabilitation centers. Methods: A multicenter cross-sectional study involving 41 nutrition rehabilitation centres (NRCs) across India was carried out to document prevalence of pulmonary tuberculosis in acute severe malnourished children admitted in NRCs. After training of the NRC staff to follow algorithm provided by national tuberculosis elimination program, children admitted to NRCs were screened for pulmonary tuberculosis. Results: A total of 4356 children were enrolled across all the sites. Gastric aspirate for Cartridge based nucleic acid amplification test (CBNAAT), tuberculin skin test (TST) and X-ray film of chest were done in more than 99% of enrolled subjects. A total of 189 children (4.3%) had pulmonary tuberculosis. Eighty-seven (1.99%) were microbiologically confirmed by positive CBNAAT. On multivariate analysis, only significant association was with history of contact with TB patient in family. Conclusions: The present results suggest that a significant proportion (>4%) of children admitted in NRCs suffer from pulmonary tuberculosis. It is feasible to improve diagnosis of tuberculosis as a whole and microbiologically confirmed TB.",

keywords = "CBNAAT, Gastric lavage, Nutritional rehabilitation center, TrueNat, Tuberculin skin test",

author = "{NRC Group} and Manjula Singh and Bhavna Dhingra and Bipra Bishnu and Dhruvendra Pandey and Anand, {Praveen K.} and Sarika Gupta and Das, {Vidyanand Ravi} and Nitin Dhochak and Kabra, {S. K.} and Amber Kumar and Arti Agarwal and Asha Dixit and Smita Saxena and Meena Verma and Prabha Desikan and Sangeeta Goyal and Sriram Ss and Namita Patel and Sarman Singh and Harish Chauhan and Pawan Kumar and Khatri, {P. K.} and Bishnoi, {R. K.} and Suthar, {R. K.} and Suresh Kumar and A. Adak and Krishanu Sinha and Arpi Mondal and Arpita Saha and Barun Santra and D. Sahana and Krishanu Roy and Krishanu Sinha and M. Paul and Sandip Mitra and Santanu Ghosh and Md Ismail and Bej, {P. K.} and D. Manna and Rabindranath Jana and S. Bhattacharya and S. Modak and Banerjee, {S. N.} and S. Sasmal and Md Shamim and Saikat Bera and Sarmistha Mukherjee and Sudip Kander and Souvik Das and Swarnali Dey",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation.",

year = "2023",

doi = "10.1007/s12098-023-04723-5",

language = "English",

journal = "Indian Journal of Pediatrics",

issn = "0019-5456",

publisher = "Springer India",

}

TY - JOUR

T1 - Pulmonary Tuberculosis in Severely Malnourished Children Admitted to Nutrition Rehabilitation Centers

T2 - A Multicenter Study

AU - NRC Group

AU - Singh, Manjula

AU - Dhingra, Bhavna

AU - Bishnu, Bipra

AU - Pandey, Dhruvendra

AU - Anand, Praveen K.

AU - Gupta, Sarika

AU - Das, Vidyanand Ravi

AU - Dhochak, Nitin

AU - Kabra, S. K.

AU - Kumar, Amber

AU - Agarwal, Arti

AU - Dixit, Asha

AU - Saxena, Smita

AU - Verma, Meena

AU - Desikan, Prabha

AU - Goyal, Sangeeta

AU - Ss, Sriram

AU - Patel, Namita

AU - Singh, Sarman

AU - Chauhan, Harish

AU - Kumar, Pawan

AU - Khatri, P. K.

AU - Bishnoi, R. K.

AU - Suthar, R. K.

AU - Kumar, Suresh

AU - Adak, A.

AU - Sinha, Krishanu

AU - Mondal, Arpi

AU - Saha, Arpita

AU - Santra, Barun

AU - Sahana, D.

AU - Roy, Krishanu

AU - Sinha, Krishanu

AU - Paul, M.

AU - Mitra, Sandip

AU - Ghosh, Santanu

AU - Ismail, Md

AU - Bej, P. K.

AU - Manna, D.

AU - Jana, Rabindranath

AU - Bhattacharya, S.

AU - Modak, S.

AU - Banerjee, S. N.

AU - Sasmal, S.

AU - Shamim, Md

AU - Bera, Saikat

AU - Mukherjee, Sarmistha

AU - Kander, Sudip

AU - Das, Souvik

AU - Dey, Swarnali

PY - 2023

Y1 - 2023

N2 - Objectives: To identify prevalence of pulmonary tuberculosis (TB) in severely malnourished children admitted to nutritional rehabilitation centers. Methods: A multicenter cross-sectional study involving 41 nutrition rehabilitation centres (NRCs) across India was carried out to document prevalence of pulmonary tuberculosis in acute severe malnourished children admitted in NRCs. After training of the NRC staff to follow algorithm provided by national tuberculosis elimination program, children admitted to NRCs were screened for pulmonary tuberculosis. Results: A total of 4356 children were enrolled across all the sites. Gastric aspirate for Cartridge based nucleic acid amplification test (CBNAAT), tuberculin skin test (TST) and X-ray film of chest were done in more than 99% of enrolled subjects. A total of 189 children (4.3%) had pulmonary tuberculosis. Eighty-seven (1.99%) were microbiologically confirmed by positive CBNAAT. On multivariate analysis, only significant association was with history of contact with TB patient in family. Conclusions: The present results suggest that a significant proportion (>4%) of children admitted in NRCs suffer from pulmonary tuberculosis. It is feasible to improve diagnosis of tuberculosis as a whole and microbiologically confirmed TB.

AB - Objectives: To identify prevalence of pulmonary tuberculosis (TB) in severely malnourished children admitted to nutritional rehabilitation centers. Methods: A multicenter cross-sectional study involving 41 nutrition rehabilitation centres (NRCs) across India was carried out to document prevalence of pulmonary tuberculosis in acute severe malnourished children admitted in NRCs. After training of the NRC staff to follow algorithm provided by national tuberculosis elimination program, children admitted to NRCs were screened for pulmonary tuberculosis. Results: A total of 4356 children were enrolled across all the sites. Gastric aspirate for Cartridge based nucleic acid amplification test (CBNAAT), tuberculin skin test (TST) and X-ray film of chest were done in more than 99% of enrolled subjects. A total of 189 children (4.3%) had pulmonary tuberculosis. Eighty-seven (1.99%) were microbiologically confirmed by positive CBNAAT. On multivariate analysis, only significant association was with history of contact with TB patient in family. Conclusions: The present results suggest that a significant proportion (>4%) of children admitted in NRCs suffer from pulmonary tuberculosis. It is feasible to improve diagnosis of tuberculosis as a whole and microbiologically confirmed TB.

KW - CBNAAT

KW - Gastric lavage

KW - Nutritional rehabilitation center

KW - TrueNat

KW - Tuberculin skin test

UR - http://www.scopus.com/inward/record.url?scp=85165315918&partnerID=8YFLogxK

U2 - 10.1007/s12098-023-04723-5

DO - 10.1007/s12098-023-04723-5

M3 - Article

C2 - 37470961

AN - SCOPUS:85165315918

SN - 0019-5456

JO - Indian Journal of Pediatrics

JF - Indian Journal of Pediatrics

ER -

Pulmonary Tuberculosis in Severely Malnourished Children Admitted to Nutrition Rehabilitation Centers: A Multicenter Study

Abstract

Keywords

UN SDGs

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