Qualitative modelling and analysis of the regulatory network of indoleamine 2, 3-dioxygenase in tumour immune escape

Jamil Ahmad; Javaria Ashraf; Kashif Asghar; Umar Khan Niazi

doi:10.1109/ICCNIT.2011.6020905

Qualitative modelling and analysis of the regulatory network of indoleamine 2, 3-dioxygenase in tumour immune escape

Jamil Ahmad
, Javaria Ashraf
, Kashif Asghar
, Umar Khan Niazi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Immune escape is a critical gateway to malignancy; it is recently discovered that Indoleamine 2, 3 Dioxygenase (IDO) is involved in suppressing T-cell immunity in pathological settings including cancer. The modeling of the biological regulatory networks (BRNs) using kinetic logics of René Thomas, a well-known and powerful approach for modeling formalism, helps in understanding their dynamical behaviors. This paper presents the dynamic behaviors of the IDO related BRN. The sustained production after tumor invasion is detrimental which is shown as a stable steady state in the results. The homeostasis of IDO and T cell mediated immune regulation in the body, which is responsible for suppressing the tumor by controlling IDO activation, is shown by a qualitative cycle.

Original language	English (UK)
Title of host publication	Proceedings of 1st International Conference on Computer Networks and Information Technology, ICCNIT'11
Pages	41-45
Number of pages	5
DOIs	https://doi.org/10.1109/ICCNIT.2011.6020905
Publication status	Published - 2011
Externally published	Yes
Event	1st International Conference on Computer Networks and Information Technology, ICCNIT'11 - Abbottabad, Pakistan Duration: 11 Jul 2011 → 13 Jul 2011

Publication series

Name	Proceedings - International Conference on Computer Networks and Information Technology

Conference

Conference	1st International Conference on Computer Networks and Information Technology, ICCNIT'11
Country/Territory	Pakistan
City	Abbottabad
Period	11/07/11 → 13/07/11

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biological regulatory network
IDO
kinetic logic
qualitative modelling
tumor

Access to Document

10.1109/ICCNIT.2011.6020905

Cite this

Ahmad, J., Ashraf, J., Asghar, K., & Niazi, U. K. (2011). Qualitative modelling and analysis of the regulatory network of indoleamine 2, 3-dioxygenase in tumour immune escape. In Proceedings of 1st International Conference on Computer Networks and Information Technology, ICCNIT'11 (pp. 41-45). Article 6020905 (Proceedings - International Conference on Computer Networks and Information Technology). https://doi.org/10.1109/ICCNIT.2011.6020905

Ahmad, Jamil ; Ashraf, Javaria ; Asghar, Kashif et al. / Qualitative modelling and analysis of the regulatory network of indoleamine 2, 3-dioxygenase in tumour immune escape. Proceedings of 1st International Conference on Computer Networks and Information Technology, ICCNIT'11. 2011. pp. 41-45 (Proceedings - International Conference on Computer Networks and Information Technology).

@inproceedings{e4e98ecdb09645b9a6e17f7f08ce1c6b,

title = "Qualitative modelling and analysis of the regulatory network of indoleamine 2, 3-dioxygenase in tumour immune escape",

abstract = "Immune escape is a critical gateway to malignancy; it is recently discovered that Indoleamine 2, 3 Dioxygenase (IDO) is involved in suppressing T-cell immunity in pathological settings including cancer. The modeling of the biological regulatory networks (BRNs) using kinetic logics of Ren{\'e} Thomas, a well-known and powerful approach for modeling formalism, helps in understanding their dynamical behaviors. This paper presents the dynamic behaviors of the IDO related BRN. The sustained production after tumor invasion is detrimental which is shown as a stable steady state in the results. The homeostasis of IDO and T cell mediated immune regulation in the body, which is responsible for suppressing the tumor by controlling IDO activation, is shown by a qualitative cycle.",

keywords = "biological regulatory network, IDO, kinetic logic, qualitative modelling, tumor",

author = "Jamil Ahmad and Javaria Ashraf and Kashif Asghar and Niazi, \{Umar Khan\}",

year = "2011",

doi = "10.1109/ICCNIT.2011.6020905",

language = "English (UK)",

isbn = "9781612849416",

series = "Proceedings - International Conference on Computer Networks and Information Technology",

pages = "41--45",

booktitle = "Proceedings of 1st International Conference on Computer Networks and Information Technology, ICCNIT'11",

note = "1st International Conference on Computer Networks and Information Technology, ICCNIT'11 ; Conference date: 11-07-2011 Through 13-07-2011",

}

Ahmad, J, Ashraf, J, Asghar, K & Niazi, UK 2011, Qualitative modelling and analysis of the regulatory network of indoleamine 2, 3-dioxygenase in tumour immune escape. in Proceedings of 1st International Conference on Computer Networks and Information Technology, ICCNIT'11., 6020905, Proceedings - International Conference on Computer Networks and Information Technology, pp. 41-45, 1st International Conference on Computer Networks and Information Technology, ICCNIT'11, Abbottabad, Pakistan, 11/07/11. https://doi.org/10.1109/ICCNIT.2011.6020905

Qualitative modelling and analysis of the regulatory network of indoleamine 2, 3-dioxygenase in tumour immune escape. / Ahmad, Jamil; Ashraf, Javaria; Asghar, Kashif et al.
Proceedings of 1st International Conference on Computer Networks and Information Technology, ICCNIT'11. 2011. p. 41-45 6020905 (Proceedings - International Conference on Computer Networks and Information Technology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Qualitative modelling and analysis of the regulatory network of indoleamine 2, 3-dioxygenase in tumour immune escape

AU - Ahmad, Jamil

AU - Ashraf, Javaria

AU - Asghar, Kashif

AU - Niazi, Umar Khan

PY - 2011

Y1 - 2011

N2 - Immune escape is a critical gateway to malignancy; it is recently discovered that Indoleamine 2, 3 Dioxygenase (IDO) is involved in suppressing T-cell immunity in pathological settings including cancer. The modeling of the biological regulatory networks (BRNs) using kinetic logics of René Thomas, a well-known and powerful approach for modeling formalism, helps in understanding their dynamical behaviors. This paper presents the dynamic behaviors of the IDO related BRN. The sustained production after tumor invasion is detrimental which is shown as a stable steady state in the results. The homeostasis of IDO and T cell mediated immune regulation in the body, which is responsible for suppressing the tumor by controlling IDO activation, is shown by a qualitative cycle.

AB - Immune escape is a critical gateway to malignancy; it is recently discovered that Indoleamine 2, 3 Dioxygenase (IDO) is involved in suppressing T-cell immunity in pathological settings including cancer. The modeling of the biological regulatory networks (BRNs) using kinetic logics of René Thomas, a well-known and powerful approach for modeling formalism, helps in understanding their dynamical behaviors. This paper presents the dynamic behaviors of the IDO related BRN. The sustained production after tumor invasion is detrimental which is shown as a stable steady state in the results. The homeostasis of IDO and T cell mediated immune regulation in the body, which is responsible for suppressing the tumor by controlling IDO activation, is shown by a qualitative cycle.

KW - biological regulatory network

KW - IDO

KW - kinetic logic

KW - qualitative modelling

KW - tumor

UR - https://www.scopus.com/pages/publications/80155182000

U2 - 10.1109/ICCNIT.2011.6020905

DO - 10.1109/ICCNIT.2011.6020905

M3 - Conference contribution

AN - SCOPUS:80155182000

SN - 9781612849416

T3 - Proceedings - International Conference on Computer Networks and Information Technology

SP - 41

EP - 45

BT - Proceedings of 1st International Conference on Computer Networks and Information Technology, ICCNIT'11

T2 - 1st International Conference on Computer Networks and Information Technology, ICCNIT'11

Y2 - 11 July 2011 through 13 July 2011

ER -

Ahmad J, Ashraf J, Asghar K, Niazi UK. Qualitative modelling and analysis of the regulatory network of indoleamine 2, 3-dioxygenase in tumour immune escape. In Proceedings of 1st International Conference on Computer Networks and Information Technology, ICCNIT'11. 2011. p. 41-45. 6020905. (Proceedings - International Conference on Computer Networks and Information Technology). doi: 10.1109/ICCNIT.2011.6020905

Qualitative modelling and analysis of the regulatory network of indoleamine 2, 3-dioxygenase in tumour immune escape

Abstract

Publication series

Conference

UN SDGs

Keywords

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