Reaching beyond pregnant women to eliminate mother-to-child transmission of syphilis in Africa

Lee A. Trope, Nalinka Saman Wijesooriya, Nathalie Broutet, Marleen Temmerman, Lori Newman

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Congenital syphilis is a devastating disease that can be prevented by screening and treatment of infected pregnant women. The WHO is leading a global initiative to eliminate mother-to-child-transmission of syphilis with a goal of ≤50 congenital syphilis cases per 100,000 live births and targets of 95% antenatal care, 95% syphilis testing, and 95% treatment coverage. We estimated current congenital syphilis rates for 43 African countries, and additional scenarios in a subset of 9 countries. Our analysis suggested that only 4 of 43 countries are likely to currently have a congenital syphilis rate ≤50 per 100,000 live births, and none of the 9 countries could reach this goal even in 5 different scenarios with improved services. To achieve the eliminate mother-to-child-transmission goal, it appears necessary to intervene beyond services for pregnant women, and decrease prevalence of syphilis in the general population as well.

Original languageEnglish
Pages (from-to)705-714
Number of pages10
JournalExpert Review of Anti-Infective Therapy
Issue number6
Publication statusPublished - Jun 2014
Externally publishedYes


  • Africa
  • Treponema pallidum
  • antenatal care
  • congenital syphilis
  • maternal syphilis
  • mother-to-child transmission
  • pregnancy


Dive into the research topics of 'Reaching beyond pregnant women to eliminate mother-to-child transmission of syphilis in Africa'. Together they form a unique fingerprint.

Cite this