TY - JOUR
T1 - Recent Advancements in Gremlin-1
T2 - Breast cancer
AU - Inam, Nimrah
AU - Hameed, Ayesha
AU - Vohra, Lubna
AU - Zeeshan, Sana
N1 - Publisher Copyright:
© 2023 Pakistan Medical Association. All rights reserved.
PY - 2023/2
Y1 - 2023/2
N2 - One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or - independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.
AB - One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or - independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.
KW - Bone Morphogenetic
KW - breast cancers
KW - Carcinogenesis
KW - Colorectal Neoplasms
KW - Organogenesis
KW - stem cells
UR - http://www.scopus.com/inward/record.url?scp=85147515705&partnerID=8YFLogxK
U2 - 10.47391/JPMA.AKUS-25
DO - 10.47391/JPMA.AKUS-25
M3 - Review article
C2 - 36788408
AN - SCOPUS:85147515705
SN - 0030-9982
VL - 73
SP - S155-S159
JO - Journal of the Pakistan Medical Association
JF - Journal of the Pakistan Medical Association
IS - 2
ER -
