Recent Advancements in Gremlin-1: Breast cancer

Nimrah Inam; Ayesha Hameed; Lubna Vohra; Sana Zeeshan

doi:10.47391/JPMA.AKUS-25

Recent Advancements in Gremlin-1: Breast cancer

Nimrah Inam, Ayesha Hameed, Lubna Vohra, Sana Zeeshan

Section of Breast Surgery, Department of Surgery, Medical College, Pakistan

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or - independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.

Original language	English (US)
Pages (from-to)	S155-S159
Journal	Journal of the Pakistan Medical Association
Volume	73
Issue number	2
DOIs	https://doi.org/10.47391/JPMA.AKUS-25
Publication status	Published - Feb 2023

Keywords

Bone Morphogenetic
Carcinogenesis
Colorectal Neoplasms
Organogenesis
breast cancers
stem cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.47391/JPMA.AKUS-25

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title = "Recent Advancements in Gremlin-1: Breast cancer",

abstract = "One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or - independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.",

keywords = "Bone Morphogenetic, Carcinogenesis, Colorectal Neoplasms, Organogenesis, breast cancers, stem cells",

author = "Nimrah Inam and Ayesha Hameed and Lubna Vohra and Sana Zeeshan",

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TY - JOUR

T1 - Recent Advancements in Gremlin-1

T2 - Breast cancer

AU - Inam, Nimrah

AU - Hameed, Ayesha

AU - Vohra, Lubna

AU - Zeeshan, Sana

PY - 2023/2

Y1 - 2023/2

N2 - One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or - independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.

AB - One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or - independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.

KW - Bone Morphogenetic

KW - Carcinogenesis

KW - Colorectal Neoplasms

KW - Organogenesis

KW - breast cancers

KW - stem cells

UR - https://www.scopus.com/pages/publications/85147515705

U2 - 10.47391/JPMA.AKUS-25

DO - 10.47391/JPMA.AKUS-25

M3 - Review article

C2 - 36788408

AN - SCOPUS:85147515705

SN - 0030-9982

VL - 73

SP - S155-S159

JO - Journal of the Pakistan Medical Association

JF - Journal of the Pakistan Medical Association

IS - 2

ER -

Recent Advancements in Gremlin-1: Breast cancer

Abstract

Keywords

UN SDGs

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