Recurrent aseptic meningitis: A rare clinical presentation of Sjogren's syndrome

Asma Basheer, Ejaz Ahmed Khan, Tahir Hashmi, Rashid Ali Khan, Arsalan Ahmad

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6 Citations (Scopus)


Sjogren's syndrome most commonly presents with dry eyes, dry mouth, joint pain and fatigue. However, recurrent aseptic meningitis, reported as the most uncommon initial symptom, was the presenting feature in our case. We present the case of a 19-year-old female with recurrent episodes of aseptic meningitis. She presented with fever, headache, vomiting and photophobia. Neurological examination showed neck stiffness. Fundoscopy was normal. On two previous occasions her cerebrospinal fluid analysis was consistent with meningitis; however, it was normal at this presentation. Review of system revealed history of fatigue and sicca symptoms since early childhood. Autoimmune workup showed antinuclear antibodies with a titer of 1:400 and positive anti SSA (Ro) antibodies that led to the diagnosis of Sjogren's syndrome. She responded well to intravenous steroids, followed by oral prednisolone and hydroxychloroquine. To conclude, diagnosis of Sjogren's syndrome may also be considered in a patient presenting with recurrent aseptic meningitis.

Original languageEnglish
Pages (from-to)1547-1549
Number of pages3
JournalJPMA. The Journal of the Pakistan Medical Association
Issue number10
Publication statusPublished - 1 Oct 2019
Externally publishedYes


  • Aseptic meningitis, Keratoconjunctivitis sicca, Sjogren's syndrome. doi:10.5455/JPMA.295727


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