Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan

P. B. Mal; J. Farooqi; S. Irfan; M. A. Hughes; E. Khan

doi:10.4103/0255-0857.188338

Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan

P. B. Mal, J. Farooqi, S. Irfan, M. A. Hughes, E. Khan

Department of Pathology and Laboratory Medicine, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We analysed susceptibility of multidrug-resistant organisms (MDROs) including New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae to chlorhexidine and compared results to their susceptible counterparts. Susceptibilities of chlorhexidine digluconate in a standard (CHX-S) preparation and two commercial disinfectants containing different CHX concentrations (2% w/v and 4% w/w) were performed. MDROs had narrower range of higher CHX-S minimum inhibitory concentrations (MICs) as compared to pan-sensitive organisms. The MIC values for commercial disinfectants products for MDROs were many folds higher (20-600 times), than CHX-S for in vitro use. Increasing antibiotic resistance among bacterial isolates can be an indirect marker of reduced susceptibility to chlorhexidine in hospital setting.

Original language	English (UK)
Pages (from-to)	346-349
Number of pages	4
Journal	Indian Journal of Medical Microbiology
Volume	34
Issue number	3
DOIs	https://doi.org/10.4103/0255-0857.188338
Publication status	Published - 1 Jul 2016

Keywords

Chlorhexidine digluconate
minimum inhibitory concentration
multidrug-resistant organism

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Mal, P. B., Farooqi, J., Irfan, S., Hughes, M. A., & Khan, E. (2016). Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan. Indian Journal of Medical Microbiology, 34(3), 346-349. https://doi.org/10.4103/0255-0857.188338

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title = "Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan",

abstract = "We analysed susceptibility of multidrug-resistant organisms (MDROs) including New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae to chlorhexidine and compared results to their susceptible counterparts. Susceptibilities of chlorhexidine digluconate in a standard (CHX-S) preparation and two commercial disinfectants containing different CHX concentrations (2\% w/v and 4\% w/w) were performed. MDROs had narrower range of higher CHX-S minimum inhibitory concentrations (MICs) as compared to pan-sensitive organisms. The MIC values for commercial disinfectants products for MDROs were many folds higher (20-600 times), than CHX-S for in vitro use. Increasing antibiotic resistance among bacterial isolates can be an indirect marker of reduced susceptibility to chlorhexidine in hospital setting.",

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author = "Mal, \{P. B.\} and J. Farooqi and S. Irfan and Hughes, \{M. A.\} and E. Khan",

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Mal, PB, Farooqi, J, Irfan, S, Hughes, MA & Khan, E 2016, 'Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan', Indian Journal of Medical Microbiology, vol. 34, no. 3, pp. 346-349. https://doi.org/10.4103/0255-0857.188338

Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan. / Mal, P. B.; Farooqi, J.; Irfan, S. et al.
In: Indian Journal of Medical Microbiology, Vol. 34, No. 3, 01.07.2016, p. 346-349.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms

T2 - Report from a tertiary care hospital in Karachi, Pakistan

AU - Mal, P. B.

AU - Farooqi, J.

AU - Irfan, S.

AU - Hughes, M. A.

AU - Khan, E.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - We analysed susceptibility of multidrug-resistant organisms (MDROs) including New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae to chlorhexidine and compared results to their susceptible counterparts. Susceptibilities of chlorhexidine digluconate in a standard (CHX-S) preparation and two commercial disinfectants containing different CHX concentrations (2% w/v and 4% w/w) were performed. MDROs had narrower range of higher CHX-S minimum inhibitory concentrations (MICs) as compared to pan-sensitive organisms. The MIC values for commercial disinfectants products for MDROs were many folds higher (20-600 times), than CHX-S for in vitro use. Increasing antibiotic resistance among bacterial isolates can be an indirect marker of reduced susceptibility to chlorhexidine in hospital setting.

AB - We analysed susceptibility of multidrug-resistant organisms (MDROs) including New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae to chlorhexidine and compared results to their susceptible counterparts. Susceptibilities of chlorhexidine digluconate in a standard (CHX-S) preparation and two commercial disinfectants containing different CHX concentrations (2% w/v and 4% w/w) were performed. MDROs had narrower range of higher CHX-S minimum inhibitory concentrations (MICs) as compared to pan-sensitive organisms. The MIC values for commercial disinfectants products for MDROs were many folds higher (20-600 times), than CHX-S for in vitro use. Increasing antibiotic resistance among bacterial isolates can be an indirect marker of reduced susceptibility to chlorhexidine in hospital setting.

KW - Chlorhexidine digluconate

KW - minimum inhibitory concentration

KW - multidrug-resistant organism

UR - https://www.scopus.com/pages/publications/84984633070

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M3 - Article

C2 - 27514958

AN - SCOPUS:84984633070

SN - 0255-0857

VL - 34

SP - 346

EP - 349

JO - Indian Journal of Medical Microbiology

JF - Indian Journal of Medical Microbiology

IS - 3

ER -

Reduced susceptibility to chlorhexidine disinfectant among New Delhi metallo-beta-lactamase-1 positive Enterobacteriaceae and other multidrug-resistant organisms: Report from a tertiary care hospital in Karachi, Pakistan

Abstract

Keywords

UN SDGs

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