Replication of European rheumatoid arthritis loci in a Pakistani population

Syed Fazal Jalil; Attya Bhatti; F. Yesim Demirci; Xingbin Wang; Iltaf Ahmed; Mushtaq Ahmed; M. Michael Barmada; Javaid M. Malik; Peter John; M. Ilyas Kamboh

doi:10.3899/jrheum.121050

Replication of European rheumatoid arthritis loci in a Pakistani population

Syed Fazal Jalil, Attya Bhatti, F. Yesim Demirci, Xingbin Wang, Iltaf Ahmed, Mushtaq Ahmed, M. Michael Barmada, Javaid M. Malik, Peter John, M. Ilyas Kamboh

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Objective. Genetic studies have identified several rheumatoid arthritis (RA) susceptibility loci in European-derived populations. The same biological pathways may be involved in determining the RA risk in different population groups. We sought to replicate the association of 33 single-nucleotide polymorphisms (SNP) from 31 RA susceptibility loci confirmed among Europeans in a unique Pakistani population. Methods. We genotyped 33 SNP in a sample of 366 Pakistanis that comprised related and unrelated cases and controls. Genotyping was performed using TaqMan assays and the results were analyzed with family case-control software. Results. Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP. Conclusion. Our observations suggest that a number of RA susceptibility loci and related pathways are shared across different populations. The Journal of Rheumatology

Original language	English
Pages (from-to)	401-407
Number of pages	7
Journal	Journal of Rheumatology
Volume	40
Issue number	4
DOIs	https://doi.org/10.3899/jrheum.121050
Publication status	Published - Apr 2013
Externally published	Yes

Keywords

Autoimmune disease
Related-unrelated association study
Rheumatoid arthritis
Susceptibility

Access to Document

10.3899/jrheum.121050

Cite this

@article{d3335bacba1b4d09aa4b334a5dbfbf92,

title = "Replication of European rheumatoid arthritis loci in a Pakistani population",

abstract = "Objective. Genetic studies have identified several rheumatoid arthritis (RA) susceptibility loci in European-derived populations. The same biological pathways may be involved in determining the RA risk in different population groups. We sought to replicate the association of 33 single-nucleotide polymorphisms (SNP) from 31 RA susceptibility loci confirmed among Europeans in a unique Pakistani population. Methods. We genotyped 33 SNP in a sample of 366 Pakistanis that comprised related and unrelated cases and controls. Genotyping was performed using TaqMan assays and the results were analyzed with family case-control software. Results. Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP. Conclusion. Our observations suggest that a number of RA susceptibility loci and related pathways are shared across different populations. The Journal of Rheumatology",

keywords = "Autoimmune disease, Related-unrelated association study, Rheumatoid arthritis, Susceptibility",

author = "Jalil, {Syed Fazal} and Attya Bhatti and Demirci, {F. Yesim} and Xingbin Wang and Iltaf Ahmed and Mushtaq Ahmed and Barmada, {M. Michael} and Malik, {Javaid M.} and Peter John and Kamboh, {M. Ilyas}",

year = "2013",

month = apr,

doi = "10.3899/jrheum.121050",

language = "English",

volume = "40",

pages = "401--407",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology",

number = "4",

}

TY - JOUR

T1 - Replication of European rheumatoid arthritis loci in a Pakistani population

AU - Jalil, Syed Fazal

AU - Bhatti, Attya

AU - Demirci, F. Yesim

AU - Wang, Xingbin

AU - Ahmed, Iltaf

AU - Ahmed, Mushtaq

AU - Barmada, M. Michael

AU - Malik, Javaid M.

AU - John, Peter

AU - Kamboh, M. Ilyas

PY - 2013/4

Y1 - 2013/4

N2 - Objective. Genetic studies have identified several rheumatoid arthritis (RA) susceptibility loci in European-derived populations. The same biological pathways may be involved in determining the RA risk in different population groups. We sought to replicate the association of 33 single-nucleotide polymorphisms (SNP) from 31 RA susceptibility loci confirmed among Europeans in a unique Pakistani population. Methods. We genotyped 33 SNP in a sample of 366 Pakistanis that comprised related and unrelated cases and controls. Genotyping was performed using TaqMan assays and the results were analyzed with family case-control software. Results. Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP. Conclusion. Our observations suggest that a number of RA susceptibility loci and related pathways are shared across different populations. The Journal of Rheumatology

AB - Objective. Genetic studies have identified several rheumatoid arthritis (RA) susceptibility loci in European-derived populations. The same biological pathways may be involved in determining the RA risk in different population groups. We sought to replicate the association of 33 single-nucleotide polymorphisms (SNP) from 31 RA susceptibility loci confirmed among Europeans in a unique Pakistani population. Methods. We genotyped 33 SNP in a sample of 366 Pakistanis that comprised related and unrelated cases and controls. Genotyping was performed using TaqMan assays and the results were analyzed with family case-control software. Results. Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP. Conclusion. Our observations suggest that a number of RA susceptibility loci and related pathways are shared across different populations. The Journal of Rheumatology

KW - Autoimmune disease

KW - Related-unrelated association study

KW - Rheumatoid arthritis

KW - Susceptibility

UR - http://www.scopus.com/inward/record.url?scp=84875838142&partnerID=8YFLogxK

U2 - 10.3899/jrheum.121050

DO - 10.3899/jrheum.121050

M3 - Article

C2 - 23378462

AN - SCOPUS:84875838142

SN - 0315-162X

VL - 40

SP - 401

EP - 407

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 4

ER -

Replication of European rheumatoid arthritis loci in a Pakistani population

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this