Resolution of Optic Disc Pit Maculopathy with Topical Brinzolamide and Nepafenac: A Case Report and Literature Review

Optic disc pit (ODP) is a rare ocular congenital anomaly. Fluid from the optic disc enters retinal layers, causing retinoschisis and inverse lamellar holes. This results in gradual visual loss. Various treatments have been tried in ODP-maculopathy (ODP-M). An early adolescent female presented with distortion and blurry vision in her right eye. Visual acuity was 6/18 in the right eye and 6/6 in the left eye. Clinical examination revealed an ODP at the temporal margin of the disc and an abnormal foveal reflex. Optic coherence tomography of the macula showed an inverse lamellar hole and schisis of various layers. Topical Brinzolamide 1% twice daily and Nepafenac 0.1% thrice daily were initiated. In the next six months, fluid from schisis cavities and the inverse lamellar hole resolved. In this case, the resolution of ODP-M occurred with topical Brinzolamide 1% and Nepafenac 0.1. Therefore, it is advised that medical treatment should be offered before any surgical intervention in such cases.