Response of platelet concentrates to pressure and temperature changes without impairment of the in vitro function

Cécile Kicken, Sven Van Poucke, Abraham Emanuel Marcus, Marcus D. Lancé, Yvonne Henskens

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background Rapid platelet concentrate (PC) transfusion is crucial for hemostatic resuscitation. Pressure-aided and warmed transfusion combined with pneumatic tube system (PTS) transport from the laboratory to the operating theatre offers a potentially rapid delivery technique. The aim of this study is a quantitative assessment of in vitro platelet function after PTS transport followed by warmed and/or pressure-aided mock transfusions. Methods Ten PC samples entered a single PTS run and were subsequently aliquoted for testing. PCs were warmed in a blood warmer and/or subjected to pressure-aided mock transfusion at 300 mm Hg on day 2 or day 7 after collection. Platelet function was assessed using light-transmission aggregometry and multiple-electrode aggregometry to measure the response to ADP, arachidonic acid, collagen, and thrombin-receptor activating peptide. Data were analyzed with non-parametric testing; P < 0.05 was considered statistically significant. Results Single PTS transport markedly reduced ADP response in fresh PCs. Seven-day storage had a pronounced effect on both ADP and collagen response. All other tested platelet agonists revealed preserved function. Subsequent warming and/or application of pressure did not significantly compromise platelet function. Conclusions Pressure-aided plus warmed transfusion and PTS transport was not found to be detrimental to the PC. Further clinical studies are required to determine safety and efficacy of the product.

Original languageEnglish
Pages (from-to)679-683
Number of pages5
JournalThrombosis Research
Issue number4
Publication statusPublished - 1 Apr 2015
Externally publishedYes


  • Aggregometry
  • Platelets
  • Pneumatic tube system
  • Transfusion


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