Risk factors for hepatitis C virus infection in patients on long-term hemodialysis

Nasir Khokhar, Ali Yawar Alam, Farah Naz, Syed Nayer Mahmood

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Objective: To estimate the frequency of hepatitis C virus (HCV) infection in patients on hemodialysis at Shifa International Hospital and determine the association of various risk factors in the acquisition of hepatitis C infection. Design: A cross-sectional analytical study. Place and Duration of Study: Shifa International Hospital from January 2002 to June 2003. Patients and methods: All patients on long-term hemodialysis in Nephrology Unit of Shifa International Hospital were studied. Their medical records were reviewed for the presence of anti-HCV in all patients. Any risk factors were noted from the patient's records and from the history of those patients who were regularly attending the dialysis unit. Results: A total of 97 patients on hemodialysis were included. Out of these, 23 (23.7%) were found to be anti-HCV positive. The mean age of HCV positive patients was 55.2±15.5 years while for the anti-HCV negative patients it was 54.9±15.1 years. There were 18 (78.3%) males in the HCV positive group while 46 (62.2%) males in the HCV negative group. The mean duration of dialysis among HCV positive patients was 2.9±2.7 years while the mean duration of dialysis in HCV negative patients was 1.51±0.86 years (p-value 0.000). Anti-HCV positive group had significantly greater proportion of patients with a history of dialysis more than 2 years (43.5% vs 9.5%), adjusted odds ratio being 0.45 (95% Cl 0.27-0.75). No significant difference in other risk factors between the two groups was found. When years of dialysis were treated as categorical variable, significant difference between the anti-HCV positive and negative groups was found. The risk of getting HCV was found to be significantly associated with increasing years of dialysis, (adjusted p-value 0.002). Conclusion: Patients on hemodialysis in our unit had 23.7% positivity of anti-HCV and history of dialysis over more than 2 years was noted to be a significant risk factor for acquisition of infection in these patients.

Original languageEnglish
Pages (from-to)326-328
Number of pages3
JournalJournal of the College of Physicians and Surgeons--Pakistan : JCPSP
Issue number6
Publication statusPublished - Jun 2005
Externally publishedYes


  • Anti-HCV
  • Hemodialysis
  • Hepatitis C


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