TY - JOUR
T1 - Risk factors for premature coronary artery disease (PCAD) in adults
T2 - A systematic review protocol
AU - Khoja, Adeel
AU - Arstall, Margaret A.
AU - Andraweera, Prabha H.
AU - Lassi, Zohra S.
AU - Zheng, Mingyue
AU - Pathirana, Maleesa M.
AU - Ali, Anna
AU - Aldridge, Emily
AU - Wittwer, Melanie R.
AU - Chaudhuri, Debajyoti D.
AU - Tavella, Rosanna
N1 - Publisher Copyright:
© 2021 Khoja A et al.
PY - 2021
Y1 - 2021
N2 - PCAD possesses a public health challenge resulting in years of productive life lost and an escalating burden on health systems. Objective of this review is to compare modifiable and non-modifiable risk factors for PCAD compared to those without PCAD. This review will include all comparative observational studies conducted in adults aged >18 years with confirmed diagnosis of PCAD (on angiography) compared to those without PCAD. Databases to be searched include; PubMed, CINAHL, Embase, Web of Science, and grey literature (Google Scholar). All identified studies will be screened for title and abstract and full-text against the inclusion criteria on Covidence software. Data relevant to exposures and outcomes will be extracted from all included studies. All studies selected for data extraction will be critically appraised for methodological quality. Meta-analysis using random-effects model will be performed using Review Manager 5.3. Effect sizes for categorical risk factors will be expressed as odds ratios with 95% confidence intervals. For risk factors measured in continuous form, mean difference (if units are consistent) otherwise standardized mean difference (if units are different across studies) will be reported. Heterogeneity between studies will be assessed using I 2 test statistics. GRADE will be used to assess the certainty of the findings.
AB - PCAD possesses a public health challenge resulting in years of productive life lost and an escalating burden on health systems. Objective of this review is to compare modifiable and non-modifiable risk factors for PCAD compared to those without PCAD. This review will include all comparative observational studies conducted in adults aged >18 years with confirmed diagnosis of PCAD (on angiography) compared to those without PCAD. Databases to be searched include; PubMed, CINAHL, Embase, Web of Science, and grey literature (Google Scholar). All identified studies will be screened for title and abstract and full-text against the inclusion criteria on Covidence software. Data relevant to exposures and outcomes will be extracted from all included studies. All studies selected for data extraction will be critically appraised for methodological quality. Meta-analysis using random-effects model will be performed using Review Manager 5.3. Effect sizes for categorical risk factors will be expressed as odds ratios with 95% confidence intervals. For risk factors measured in continuous form, mean difference (if units are consistent) otherwise standardized mean difference (if units are different across studies) will be reported. Heterogeneity between studies will be assessed using I 2 test statistics. GRADE will be used to assess the certainty of the findings.
KW - Age
KW - Coronary artery disease
KW - Gender
KW - Premature coronary artery disease
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85123467253&partnerID=8YFLogxK
U2 - 10.12688/f1000research.74926.1
DO - 10.12688/f1000research.74926.1
M3 - Article
C2 - 35106139
AN - SCOPUS:85123467253
SN - 2046-1402
VL - 10
JO - F1000Research
JF - F1000Research
M1 - 1228
ER -
